Are trade‐offs really the key drivers of ageing and life span?

AA Cohen, CFD Coste, XY Li, S Bourg… - Functional …, 2020 - Wiley Online Library
Current thinking in life‐history theory and the biology of ageing suggests that ageing rates,
and consequently life spans, evolve largely as a function of trade‐offs with reproduction …

Trade-offs (and constraints) in organismal biology

T Garland Jr, CJ Downs… - … and biochemical zoology, 2022 - journals.uchicago.edu
Trade-offs and constraints are inherent to life, and studies of these phenomena play a
central role in both organismal and evolutionary biology. Trade-offs can be defined …

Integrating theoretical and empirical approaches for a robust understanding of endocrine flexibility

JL Grindstaff, LE Beaty, M Ambardar… - Journal of …, 2022 - journals.biologists.com
There is growing interest in studying hormones beyond single 'snapshot'measurements, as
recognition that individual variation in the endocrine response to environmental change may …

Trade-offs, pleiotropy, and shared molecular pathways: a unified view of constraints on adaptation

AA Mauro, CK Ghalambor - Integrative and Comparative Biology, 2020 - academic.oup.com
The concept of trade-offs permeates our thinking about adaptive evolution because they are
exhibited at every level of biological organization, from molecular and cellular processes to …

Hormonal pleiotropy structures genetic covariance

TN Wittman, CD Robinson, JW McGlothlin… - Evolution …, 2021 - academic.oup.com
Quantitative genetic theory proposes that phenotypic evolution is shaped by G, the matrix of
genetic variances and covariances among traits. In species with separate sexes, the …

Sex steroids as mediators of phenotypic integration, genetic correlations, and evolutionary transitions

RM Cox - Molecular and cellular endocrinology, 2020 - Elsevier
In recent decades, endocrinologists have increasingly adopted evolutionary methods and
perspectives to characterize the evolution of the vertebrate endocrine system and leverage it …

Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells

PT Dolan, S Taguwa, MA Rangel, A Acevedo, T Hagai… - Elife, 2021 - elifesciences.org
Dengue virus (DENV) cycles between mosquito and mammalian hosts. To examine how
DENV populations adapt to these different host environments, we used serial passage in …

Evolution of hormone-phenotype couplings and hormone-genome interactions

RM Cox, MD Hale, TN Wittman, CD Robinson… - Hormones and …, 2022 - Elsevier
When selection favors a new relationship between a cue and a hormonally mediated
response, adaptation can proceed by altering the hormonal signal that is produced or by …

The Danaid theory of aging

MJ Wensink, AA Cohen - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
The classical evolutionary theories of aging suggest that aging evolves due to insufficient
selective pressure against it. In these theories, declining selection pressure with age leads …

Trade-off shapes diversity in eco-evolutionary dynamics

F Farahpour, M Saeedghalati, VS Brauer, D Hoffmann - elife, 2018 - elifesciences.org
We introduce an Interaction-and Trade-off-based Eco-Evolutionary Model (ITEEM), in which
species are competing in a well-mixed system, and their evolution in interaction trait space is …