11β-HSD As a new target in pharmacotherapy of metabolic diseases

D Kupczyk, R Bilski, M Kozakiewicz… - International journal of …, 2022 - mdpi.com
Glucocorticoids (GCs), which are secreted by the adrenal cortex, are important regulators in
the metabolism of carbohydrates, lipids, and proteins. For the proper functioning of the body …

11β-Hydroxysteroid Dehydrogenase Type 1 as a Potential Treatment Target in Cardiovascular Diseases

D Kupczyk, R Studzińska, R Kołodziejska… - Journal of Clinical …, 2022 - mdpi.com
Glucocorticoids (GCs) belong to the group of steroid hormones. Their representative in
humans is cortisol. GCs are involved in most physiological processes of the body and play a …

Novel 2-(Adamantan-1-ylamino)Thiazol-4(5H)-One Derivatives and Their Inhibitory Activity towards 11β-HSD1—Synthesis, Molecular Docking and In Vitro Studies

R Studzińska, D Kupczyk, W Płaziński… - International Journal of …, 2021 - mdpi.com
A common mechanism in which glucocorticoids participate is suggested in the pathogenesis
of such metabolic diseases as obesity, metabolic syndrome, or Cushing's syndrome. The …

MgO nanopowders catalyzed synthesis of pyrano [4, 3‐d] thiazolo [3, 2‐a] pyrimidine derivatives

M Khalaj, SM Mousavi‐Safavi… - Applied …, 2020 - Wiley Online Library
A cubic phase of pure MgO nanopowders was prepared in an aqueous solution containing
freshly squeezed orange juice with pulp and characterized by X‐ray diffraction (XRD), field …

A Novel N-Tert-Butyl Derivatives of Pseudothiohydantoin as Potential Target in Anti-Cancer Therapy

D Kupczyk, R Studzińska, S Baumgart, R Bilski… - Molecules, 2021 - mdpi.com
Tumors are currently more and more common all over the world; hence, attempts are being
made to explain the biochemical processes underlying their development. The search for …

[PDF][PDF] Studzi nska

D Kupczyk - Clin. Med, 2022 - academia.edu
Glucocorticoids (GCs) belong to the group of steroid hormones. Their representative in
humans is cortisol. GCs are involved in most physiological processes of the body and play a …

[HTML][HTML] Synthesis of Carborane–Thiazole Conjugates as Tyrosinase and 11β-Hydroxysteroid Dehydrogenase Inhibitors: Antiproliferative Activity and Molecular …

B Donarska, J Cytarska, D Kołodziej-Sobczak… - Molecules, 2024 - mdpi.com
The presented study depicts the synthesis of 11 carborane–thiazole conjugates with
anticancer activity, as well as an evaluation of their biological activity as inhibitors of two …

Synthesis of the N‐methyl Derivatives of 2‐Aminothiazol‐4(5H)‐one and Their Interactions with 11βHSD1‐Molecular Modeling and in Vitro Studies

R Studzińska, R Kołodziejska, W Płaziński… - Chemistry & …, 2019 - Wiley Online Library
Abstract 11β‐Hydroxysteroid dehydrogenase type 1 (11β‐HSD1) is an enzyme that affects
the body's cortisol levels. The inhibition of its activity can be used in the treatment of …

Synthesis of Novel 2-(Isopropylamino)thiazol-4(5H)-one Derivatives and Their Inhibitory Activity of 11β-HSD1 and 11β-HSD2 in Aspect of Carcinogenesis Prevention

D Kupczyk, R Studzińska, R Bilski, S Baumgart… - Molecules, 2020 - mdpi.com
Glucocorticoid metabolism at the tissue level is regulated by two isoenzymes 11β-
hydroxysteroid dehydrogenase (11β-HSD), which mutually convert biologically active …

Application of ELISA Technique and Human Microsomes in the Search for 11β‐Hydroxysteroid Dehydrogenase Inhibitors

D Kupczyk, R Studzińska, R Bilski… - BioMed Research …, 2019 - Wiley Online Library
The metabolic syndrome is defined by impaired carbohydrate metabolism and lipid
disorders and often accompanied by hypertension, all of which will lead to obesity and …