[HTML][HTML] The JAK-STAT pathway at 30: Much learned, much more to do
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
The JAK/STAT signaling pathway: from bench to clinic
X Hu, J Li, M Fu, X Zhao, W Wang - Signal transduction and targeted …, 2021 - nature.com
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
The roles of Polycomb repressive complexes in mammalian development and cancer
A Piunti, A Shilatifard - Nature reviews Molecular cell biology, 2021 - nature.com
More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …
Acute lymphoblastic leukaemia
F Malard, M Mohty - The Lancet, 2020 - thelancet.com
Acute lymphoblastic leukaemia develops in both children and adults, with a peak incidence
between 1 year and 4 years. Most acute lymphoblastic leukaemia arises in healthy …
between 1 year and 4 years. Most acute lymphoblastic leukaemia arises in healthy …
The roles of DNA, RNA and histone methylation in ageing and cancer
Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …
and RNA. The methylation of chromatin components is highly conserved as it helps …
Histone lysine methyltransferases in biology and disease
D Husmann, O Gozani - Nature structural & molecular biology, 2019 - nature.com
The precise temporal and spatial coordination of histone lysine methylation dynamics across
the epigenome regulates virtually all DNA-templated processes. A large number of histone …
the epigenome regulates virtually all DNA-templated processes. A large number of histone …
The evolution of acute lymphoblastic leukemia research and therapy at MD Anderson over four decades
Progress in the research and therapy of adult acute lymphoblastic leukemia (ALL) is
accelerating. This analysis summarizes the data derived from the clinical trials conducted at …
accelerating. This analysis summarizes the data derived from the clinical trials conducted at …
Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours
Abstract Analysis of molecular aberrations across multiple cancer types, known as pan-
cancer analysis, identifies commonalities and differences in key biological processes that …
cancer analysis, identifies commonalities and differences in key biological processes that …
Advances in the diagnosis and treatment of pediatric acute lymphoblastic leukemia
H Inaba, CH Pui - Journal of clinical medicine, 2021 - mdpi.com
The outcomes of pediatric acute lymphoblastic leukemia (ALL) have improved remarkably
during the last five decades. Such improvements were made possible by the incorporation of …
during the last five decades. Such improvements were made possible by the incorporation of …
Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor
Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …