Antimicrobial peptides

AA Bahar, D Ren - Pharmaceuticals, 2013 - mdpi.com
The rapid increase in drug-resistant infections has presented a serious challenge to
antimicrobial therapies. The failure of the most potent antibiotics to kill “superbugs” …

Amphipathic, α‐helical antimicrobial peptides

A Tossi, L Sandri, A Giangaspero - Peptide Science, 2000 - Wiley Online Library
Gene‐encoded antimicrobial peptides are an important component of host defense in
animals ranging from insects to mammals. They do not target specific molecular receptors …

In pursuit of next-generation therapeutics: Antimicrobial peptides against superbugs, their sources, mechanism of action, nanotechnology-based delivery, and clinical …

A Thakur, A Sharma, HK Alajangi, PK Jaiswal… - International Journal of …, 2022 - Elsevier
Antimicrobial peptides (AMPs) attracted attention as potential source of novel antimicrobials.
Multi-drug resistant (MDR) infections have emerged as a global threat to public health in …

[HTML][HTML] Structural features of helical antimicrobial peptides: their potential to modulate activity on model membranes and biological cells

M Dathe, T Wieprecht - Biochimica et Biophysica Acta (BBA) …, 1999 - Elsevier
Antibacterial, membrane-lytic peptides belong to the innate immune system and host
defense mechanism of a multitude of animals and plants. The largest group of peptide …

Melittin: a membrane-active peptide with diverse functions

H Raghuraman, A Chattopadhyay - Bioscience reports, 2007 - portlandpress.com
Melittin is the principal toxic component in the venom of the European honey bee Apis
mellifera and is a cationic, hemolytic peptide. It is a small linear peptide composed of 26 …

Anti-inflammatory applications of melittin, a major component of bee venom: detailed mechanism of action and adverse effects

G Lee, H Bae - Molecules, 2016 - mdpi.com
Inflammation is a pervasive phenomenon triggered by the innate and adaptive immune
systems to maintain homeostasis. The phenomenon normally leads to recovery from …

Strategies for oral delivery of bioactive peptides with focus on debittering and masking

A Mirzapour-Kouhdasht, DJ McClements… - npj Science of …, 2023 - nature.com
Protein hydrolysis is a process used in the food industry to generate bioactive peptides of
low molecular weight and with additional health benefits, such as antihypertensive …

Antimicrobial peptides as anti-infective agents in pre-post-antibiotic era?

T Rončević, J Puizina, A Tossi - International journal of molecular …, 2019 - mdpi.com
Resistance to antibiotics is one of the main current threats to human health and every year
multi-drug resistant bacteria are infecting millions of people worldwide, with many dying as a …

[HTML][HTML] Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activity

N Sitaram, R Nagaraj - Biochimica et Biophysica Acta (BBA)-Biomembranes, 1999 - Elsevier
Species right across the evolutionary scale from insects to mammals use peptides as part of
their host-defense system to counter microbial infection. The primary structures of a large …

Antimicrobial peptides: new candidates in the fight against bacterial infections

O Toke - Peptide Science: Original Research on Biomolecules, 2005 - Wiley Online Library
Antimicrobial peptides (AMPs) of innate origin are agents of the most ancient form of
defense systems. They can be found in a wide variety of species ranging from bacteria …