Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …

The physical characteristics of tumours are intricately linked to the tumour phenotype and
difficulties during treatment. Many factors contribute to the increased stiffness of tumours; …

Although mutations leading to a compromised nuclear envelope cause diseases such as
muscular dystrophies or accelerated aging, the consequences of mechanically induced …

Defects in the architecture or integrity of the nuclear envelope are associated with a variety
of human diseases. Micronuclei, one common nuclear aberration, are an origin for …

Mutations in the LMNA gene, which encodes the nuclear envelope (NE) proteins lamins A/C,
cause Emery–Dreifuss muscular dystrophy, congenital muscular dystrophy and other …

Abstract Taxanes (Taxol/paclitaxel, Docetaxel/taxotere) are a key group of successful drugs
commonly used in chemotherapy to treat several major malignant tumors also as a front-line …

Background: For more than a century, diagnostic pathologists have used morphologic
abnormalities of the nucleus as essential diagnostic features to distinguish benign from …

Cancer metastasis, ie, the spreading of tumor cells from the primary tumor to distant organs,
is responsible for the vast majority of cancer deaths. In the process, cancer cells migrate …

The nuclear envelope is often depicted as a static barrier that regulates access between the
nucleus and the cytosol. However, recent research has identified many conditions in …

The process in which locally confined epithelial malignancies progressively evolve into
invasive cancers is often promoted by unjamming, a phase transition from a solid-like to a …