Background The development of an autistic brain is a highly complex process as evident
from the involvement of various genetic and non-genetic factors in the etiology of the autism …

Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disease originating from
combined genetic and environmental factors. Post‐mortem human studies and some animal …

Altered excitatory/inhibitory (E/I) balance is implicated in neuropsychiatric and
neurodevelopmental disorders, but the underlying genetic etiology remains poorly …

Repeated exposure to opioids causes tolerance, which limits their analgesic utility and
contributes to overdose and abuse liability. However, the molecular mechanisms …

Abstract Background The Xp22. 11 locus that encompasses PTCHD1, DDX53, and the long
noncoding RNA PTCHD1-AS is frequently disrupted in male subjects with autism spectrum …

RNA analysis at the cellular resolution in the human brain is challenging. Here, we describe
an optimised approach for detecting single RNA transcripts in a cell-type specific manner in …

Autism spectrum disorder (ASD) is a genetic heterogeneous neurodevelopmental disorder
that is characterized by impairments in social interaction and speech development and is …

Over the last one and a half decades, copy number variation and whole-genome
sequencing studies have illuminated the considerable genetic heterogeneity that underlies …

Deleterious mutations in patchd1 domain containing 1 (PTCHD1) gene have been identified
in patients with intellectual disability and/or autism spectrum disorder (ASD). To clarify the …

Abstract Interferon-γ (IFN-γ), an important mediator of the antiviral immune response, can
also act as a neuromodulator. CNS IFN-γ levels rise acutely in response to infection and …