Pluripotent stem cells can differentiate into nearly all types of cells in the body. This unique
potential provides significant promise for cell-based therapies to restore tissues or organs …

Abstract Kruppel-like factor 4 (KLF4) is highly expressed in more than 70% of breast cancers
and functions as an oncogene. However, an exact mechanism by which KLF4 enhances …

Summary O-linked-N-acetylglucosamine (O-GlcNAc) has emerged as a critical regulator of
diverse cellular processes, but its role in embryonic stem cells (ESCs) and pluripotency has …

Stem cell transplantation is a potential therapy for regenerative medicine, which aims to
restore tissues damaged by trauma, aging, and diseases. Since its conception in the late …

Background Novel developmental functions have been attributed to the P2X7 receptor
(P2X7R) including proliferation stimulation and neural differentiation. Mouse embryonic …

Pluripotent embryonic stem cells (ESCs) must select between alternative fates of self-
renewal and lineage commitment at each division during continuous proliferation. Heparan …

Mesenchymal stromal cells (MSCs) are a heterogeneous population, which contain several
cell phenotypes: mesenchymal stem cells, progenitor cells, fibroblasts and other type of …

The initiation of heterogeneity within a population of phenotypically identical progenitors is a
critical event for the onset of morphogenesis and differentiation patterning. Gap junction …

Multilineage-differentiating stress-enduring (Muse) cells exhibit the core characteristics of
pluripotent stem cells, namely, the expression of pluripotency markers and the capacity for …

The objective of this study was to assess the viability and cryotolerance of zebu embryos
produced in vitro with or without the addition of fetal calf serum (FCS) and forskolin (F) …