DNA phosphoester bonds are exceedingly resistant to hydrolysis in the absence of chemical
or enzymatic catalysts. This property is particularly important for organisms with large …

Recent results have shown that the human malaria-resistant hemoglobin S mutation
originates de novo more frequently in the gene and in the population where it is of adaptive …

Self-catalyzed DNA depurination is a sequence-specific physiological mechanism mediated
by spontaneous extrusion of a stem-loop catalytic intermediate. Hydrolysis of the 5′ G …

Among the different types of DNA damage that occur endogenously in the cell, depurination
is especially prevalent. These lesions can initiate mutagenesis and have been implicated in …

Solid-state nanopores are an emerging technology for the detection and analysis of
biomolecules at the single-molecule level. Consisting of one or more nanometer-scale …

The guidelines provided by American College of Medical Genetics and Genomics (ACMG)
and the Association of Molecular Pathology (AMP)(ACMG/AMP guidelines) suggest a …

博士 (医学) 甲第 771 号 (主論文の要旨, 要約, 審査結果の要旨, 本文), 著者名: Yoko INOUE,
Osamu MACHIDA, Yosuke KITA, Toshiyuki YAMAMOTO, タイトル: Need for revision of the …

The human β-globin, δ-globin and ɛ-globin genes contain almost identical coding strand
sequences centered about codon 6 having potential to form a stem-loop with a 5′ GAGG …

Solid-state (SS) nanopores emerged as a molecular detection platform in 2001, offering
many advantages over their biological counterparts, &agr;-hemolysin nanopores (&agr;-HL) …

Depurination occurs via hydrolysis of the purine-deoxyribose glycosyl bond and causes
nucleic acid damage. In particular, the DNA sequences that can undergo a self-catalyzed …