The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …

The key hallmark of stem cells is their ability to self-renew while keeping a differentiation
potential. Intrinsic and extrinsic cell factors may contribute to a decline in these stem cell …

Ever since the introduction of thrombolysis and the subsequent expansion of endovascular
treatments for acute ischemic stroke, it remains to be identified why the actual outcomes are …

Our understanding of how capillary blood flow and oxygen distribute across cortical layers to
meet the local metabolic demand is incomplete. We addressed this question by using two …

The cerebrovascular system continuously delivers oxygen and energy substrates to the
brain, which is one of the organs with the highest basal energy requirement in mammals …

Molecular oxygen (O 2) is a key player in cell mitochondrial function, redox balance and
oxidative stress, normal tissue function and many common disease states. Various chemical …

Optical coherence tomography (OCT) allows label-free imaging of red blood cell (RBC) flux
within capillaries with high spatio-temporal resolution. In this study, we utilized time-series …

Neuroscience is a technology‐driven discipline and brain energy metabolism is no
exception. Once satisfied with mapping metabolic pathways at organ level, we are now …

Cerebrovascular dysfunction has an important role in the pathogenesis of multiple brain
disorders. Measurement of hemodynamic responses in vivo can be challenging, particularly …

The underlying factors promoting increased mitochondrial proteins, mtDNA, and dilation to
mitochondrial-specific agents in male rats following tMCAO are not fully elucidated. Our goal …