Defining physiological normoxia for improved translation of cell physiology to animal models and humans
TP Keeley, GE Mann - Physiological reviews, 2019 - journals.physiology.org
The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
Relevance of oxygen concentration in stem cell culture for regenerative medicine
C Mas-Bargues, J Sanz-Ros… - International journal of …, 2019 - mdpi.com
The key hallmark of stem cells is their ability to self-renew while keeping a differentiation
potential. Intrinsic and extrinsic cell factors may contribute to a decline in these stem cell …
potential. Intrinsic and extrinsic cell factors may contribute to a decline in these stem cell …
Dynamic capillary stalls in reperfused ischemic penumbra contribute to injury: a hyperacute role for neutrophils in persistent traffic jams
Ever since the introduction of thrombolysis and the subsequent expansion of endovascular
treatments for acute ischemic stroke, it remains to be identified why the actual outcomes are …
treatments for acute ischemic stroke, it remains to be identified why the actual outcomes are …
More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction
Our understanding of how capillary blood flow and oxygen distribute across cortical layers to
meet the local metabolic demand is incomplete. We addressed this question by using two …
meet the local metabolic demand is incomplete. We addressed this question by using two …
Topology and hemodynamics of the cortical cerebrovascular system
S Hirsch, J Reichold, M Schneider… - Journal of Cerebral …, 2012 - journals.sagepub.com
The cerebrovascular system continuously delivers oxygen and energy substrates to the
brain, which is one of the organs with the highest basal energy requirement in mammals …
brain, which is one of the organs with the highest basal energy requirement in mammals …
Imaging of oxygen and hypoxia in cell and tissue samples
DB Papkovsky, RI Dmitriev - Cellular and molecular life sciences, 2018 - Springer
Molecular oxygen (O 2) is a key player in cell mitochondrial function, redox balance and
oxidative stress, normal tissue function and many common disease states. Various chemical …
oxidative stress, normal tissue function and many common disease states. Various chemical …
Spatio-temporal dynamics of cerebral capillary segments with stalling red blood cells
Optical coherence tomography (OCT) allows label-free imaging of red blood cell (RBC) flux
within capillaries with high spatio-temporal resolution. In this study, we utilized time-series …
within capillaries with high spatio-temporal resolution. In this study, we utilized time-series …
Current technical approaches to brain energy metabolism
Neuroscience is a technology‐driven discipline and brain energy metabolism is no
exception. Once satisfied with mapping metabolic pathways at organ level, we are now …
exception. Once satisfied with mapping metabolic pathways at organ level, we are now …
In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain
K Kisler, D Lazic, MD Sweeney, S Plunkett… - Nature protocols, 2018 - nature.com
Cerebrovascular dysfunction has an important role in the pathogenesis of multiple brain
disorders. Measurement of hemodynamic responses in vivo can be challenging, particularly …
disorders. Measurement of hemodynamic responses in vivo can be challenging, particularly …
Cerebrovascular function and mitochondrial bioenergetics after ischemia-reperfusion in male rats
I Rutkai, I Merdzo, SV Wunnava… - Journal of Cerebral …, 2019 - journals.sagepub.com
The underlying factors promoting increased mitochondrial proteins, mtDNA, and dilation to
mitochondrial-specific agents in male rats following tMCAO are not fully elucidated. Our goal …
mitochondrial-specific agents in male rats following tMCAO are not fully elucidated. Our goal …