Malformations of cerebral cortical development include a wide range of developmental
disorders that are common causes of neurodevelopmental delay and epilepsy. In addition …

The study of human developmental microcephaly is providing important insights into brain
development. It has become clear that developmental microcephalies are associated with …

Centriole duplication involves the growth of a procentriole next to the parental centriole.
Mutations in STIL and CPAP/CENPJ cause primary microcephaly (MCPH). Here, we show …

Centrioles are microtubule-based core components of centrosomes and cilia. They are
duplicated exactly once during S-phase progression. Central to formation of each new …

Control of centriole number is crucial for genome stability and ciliogenesis. Here, we
characterize the role of human STIL, a protein that displays distant sequence similarity to the …

Centrioles are key structural elements of centrosomes and primary cilia. In mammals, only a
few proteins including PLK4, CPAP (CENPJ), SAS6, CEP192, CEP152 and CEP135 have …

Malformations of cortical development (MCDs) are an important cause of epilepsy and an
extremely interesting group of disorders from the perspective of brain development and its …

The formation of complex nervous systems requires processes that coordinate proliferation,
migration and differentiation of neuronal cells. The remarkable morphological …

Most animal cells contain a centrosome, which comprises a pair of centrioles surrounded by
an ordered pericentriolar matrix (PCM). Although the role of this organelle in organizing the …

The centrosome functions as the main microtubule-organizing center of animal cells and is
crucial for several fundamental cellular processes [1]. Abnormalities in centrosome number …