[HTML][HTML] Metazoan micrornas
DP Bartel - Cell, 2018 - cell.com
MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …
Clustered miRNAs and their role in biological functions and diseases
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells
Syncytial skeletal muscle cells contain hundreds of nuclei in a shared cytoplasm. We
investigated nuclear heterogeneity and transcriptional dynamics in the uninjured and …
investigated nuclear heterogeneity and transcriptional dynamics in the uninjured and …
ZSWIM8 destabilizes many murine microRNAs and is required for proper embryonic growth and development
MicroRNAs (miRNAs) pair to sites in mRNAs to direct the degradation of these RNA
transcripts. Conversely, certain RNA transcripts can direct the degradation of particular …
transcripts. Conversely, certain RNA transcripts can direct the degradation of particular …
MicroRNAs in placental health and disease
JF Mouillet, Y Ouyang, CB Coyne… - American journal of …, 2015 - Elsevier
MicroRNAs (miRNAs) constitute a large family of small noncoding RNAs that are encoded
by the genomes of most organisms. They regulate gene expression through …
by the genomes of most organisms. They regulate gene expression through …
The Dlk1-Gtl2 locus preserves LT-HSC function by inhibiting the PI3K-mTOR pathway to restrict mitochondrial metabolism
Summary The mammalian imprinted Dlk1-Gtl2 locus produces multiple non-coding RNAs
(ncRNAs) from the maternally inherited allele, including the largest miRNA cluster in the …
(ncRNAs) from the maternally inherited allele, including the largest miRNA cluster in the …
Biomolecular condensates: Sequence determinants of phase separation, microstructural organization, enzymatic activity, and material properties
BS Schuster, RM Regy, EM Dolan… - The journal of …, 2021 - ACS Publications
This perspective article highlights recent progress and emerging challenges in
understanding the formation and function of membraneless organelles (MLOs). A long-term …
understanding the formation and function of membraneless organelles (MLOs). A long-term …
Differential microRNA expression in human placentas of term intra-uterine growth restriction that regulates target genes mediating angiogenesis and amino acid …
Placental insufficiency leading to intrauterine growth restriction (IUGR) demonstrates
perturbed gene expression affecting placental angiogenesis and nutrient transfer from …
perturbed gene expression affecting placental angiogenesis and nutrient transfer from …
Long noncoding RNA functionality in imprinted domain regulation
WA MacDonald, MRW Mann - PLoS genetics, 2020 - journals.plos.org
Genomic imprinting is a parent-of-origin dependent phenomenon that restricts transcription
to predominantly one parental allele. Since the discovery of the first long noncoding RNA …
to predominantly one parental allele. Since the discovery of the first long noncoding RNA …
Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas
K Inoue, N Ogonuki, S Kamimura, H Inoue… - Nature …, 2020 - nature.com
Somatic cell nuclear transfer (SCNT) in mammals is an inefficient process that is frequently
associated with abnormal phenotypes, especially in placentas. Recent studies …
associated with abnormal phenotypes, especially in placentas. Recent studies …