The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

As a point of convergence for numerous oncogenic signaling pathways, signal transducer
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and has an
exceedingly low median overall survival of only 15 months. Current standard-of-care for …

Pulmonary fibrosis is a progressive inflammatory disease with high mortality and limited
therapeutic options. Previous genetic and immunologic investigations suggest common …

Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …

ERK1/2 is an important subfamily of mitogen‐activated protein kinases that control a broad
range of cellular activities and physiological processes. ERK1/2 can be activated transiently …

Cancer growth is controlled by cancer cells (cell intrinsic phenomenon), but also by the
immune cells in the tumor microenvironment (cell extrinsic phenomenon). Thus cancer …

Immune mechanisms are known to control the pathogenesis of atherosclerosis. However,
the exact role of DCs, which are essential for priming of immune responses, remains elusive …

Activation of the transcription factor STAT3 is thought to potently promote oncogenesis in a
variety of tissues, leading to intense efforts to develop STAT3 inhibitors for many tumors …

Purpose: This study aims to profile the expressions of 156 microRNAs (miRNA) in
hepatocellular carcinoma (HCC) and to characterize the functions of miR-222, the most …