Enhancer-associated H3K4 methylation safeguards in vitro germline competence
T Bleckwehl, G Crispatzu, K Schaaf, P Respuela… - Nature …, 2021 - nature.com
Germline specification in mammals occurs through an inductive process whereby competent
cells in the post-implantation epiblast differentiate into primordial germ cells (PGC). The …
cells in the post-implantation epiblast differentiate into primordial germ cells (PGC). The …
[HTML][HTML] Developmental phenomics suggests that H3K4 monomethylation confers multi-level phenotypic robustness
How histone modifications affect animal development remains difficult to ascertain. Despite
the prevalence of histone 3 lysine 4 monomethylation (H3K4me1) on enhancers …
the prevalence of histone 3 lysine 4 monomethylation (H3K4me1) on enhancers …
Transcriptional factors mediated reprogramming to pluripotency
N Fatima, M Saif Ur Rahman, M Qasim… - Current stem cell …, 2024 - benthamdirect.com
A unique kind of pluripotent cell, ie, Induced pluripotent stem cells (iPSCs), now being
targeted for iPSC synthesis, are produced by reprogramming animal and human …
targeted for iPSC synthesis, are produced by reprogramming animal and human …
H3K4 trimethylation is required for postnatal pancreatic endocrine cell functional maturation
SA Campbell, J Bégin, CL McDonald, B Vanderkruk… - Diabetes, 2021 - Am Diabetes Assoc
During pancreas development, endocrine progenitors differentiate into the islet cell
subtypes, which undergo further functional maturation in postnatal islet development. In islet …
subtypes, which undergo further functional maturation in postnatal islet development. In islet …
MLL3/MLL4 histone methyltranferase activity dependent chromatin organization at enhancers during embryonic stem cell differentiation
SUMMARY MLL3 (KMT2C) and MLL4 (KMT2D), the major mono-methyltransferases of
histone H3 lysine 4 (H3K4), are required for cellular differentiation and embryonic …
histone H3 lysine 4 (H3K4), are required for cellular differentiation and embryonic …
Developmental phenomics suggests that H3K4 monomethylation catalyzed by Trr functions as a phenotypic capacitor
How epigenetic modulators of gene regulation affect the development and evolution of
animals has been difficult to ascertain. Despite the widespread presence of histone 3 lysine …
animals has been difficult to ascertain. Despite the widespread presence of histone 3 lysine …
The relevance of the epigenetic features of enhancers for germline competence
T Bleckwehl - 2021 - kups.ub.uni-koeln.de
Primordial germ cells (PGC) are the precursor of the gametes, which safeguard the
transmission of genetic information to the next generation. In mammals, germline …
transmission of genetic information to the next generation. In mammals, germline …