Abstract The dopamine (DAT), serotonin (SERT), and norepinephrine (NET) transporters,
which are collectively referred to as monoamine transporters (MATs), play significant roles in …

Neurotransmitter transporters (NTTs) are involved in the fine-tuning of brain neurotransmitter
homeostasis. As such, they are implicated in a plethora of complex behaviors, including …

Human serotine transporter (hSERT) is one of the most influential drug targets, and its
allosteric modulators (eg, escitalopram) have emerged to be the next-generation medication …

Human dopamine transporter (hDAT) regulates the reuptake of extracellular dopamine (DA)
and is an essential therapeutic target for central nervous system (CNS) diseases. The …

Vilazodone is a novel antidepressant used for the treatment of major depressive disorder
(MDD) with a primary action mechanism of inhibiting the human serotonin reuptake …

Membrane transporters mediate cellular uptake of nutrients, signaling molecules, and drugs.
Their overall mechanisms are often well understood, but the structural features setting their …

The serotonin transporter (SERT) terminates neurotransmission by transporting serotonin
from the synapse into the pre-synaptic nerve terminal. Altered SERT function leads to …

The dopamine transporter (DAT) serves a pivotal role in controlling dopamine (DA)-
mediated neurotransmission by clearing DA from synaptic and perisynaptic spaces and …

Hundreds of millions of US dollars are invested in the research and development of a single
drug. Lead compound development is an area ripe for new design strategies. Therapeutic …

Background and Purpose Radiation therapy‐induced gastrointestinal distress is partly
associated with the elimination of gut microbiota. The effectiveness of 5‐HT receptor …