Overview of monoamine transporters
S Aggarwal, OV Mortensen - Current protocols in …, 2017 - Wiley Online Library
Abstract The dopamine (DAT), serotonin (SERT), and norepinephrine (NET) transporters,
which are collectively referred to as monoamine transporters (MATs), play significant roles in …
which are collectively referred to as monoamine transporters (MATs), play significant roles in …
Allosteric modulation of neurotransmitter transporters as a therapeutic strategy
Neurotransmitter transporters (NTTs) are involved in the fine-tuning of brain neurotransmitter
homeostasis. As such, they are implicated in a plethora of complex behaviors, including …
homeostasis. As such, they are implicated in a plethora of complex behaviors, including …
Molecular mechanism for the allosteric inhibition of the human serotonin transporter by antidepressant escitalopram
W Xue, T Fu, S Deng, F Yang, J Yang… - ACS chemical …, 2022 - ACS Publications
Human serotine transporter (hSERT) is one of the most influential drug targets, and its
allosteric modulators (eg, escitalopram) have emerged to be the next-generation medication …
allosteric modulators (eg, escitalopram) have emerged to be the next-generation medication …
Structure-based discovery of a novel allosteric inhibitor against human dopamine transporter
S Deng, H Zhang, R Gou, D Luo, Z Liu… - Journal of chemical …, 2023 - ACS Publications
Human dopamine transporter (hDAT) regulates the reuptake of extracellular dopamine (DA)
and is an essential therapeutic target for central nervous system (CNS) diseases. The …
and is an essential therapeutic target for central nervous system (CNS) diseases. The …
The binding mode of vilazodone in the human serotonin transporter elucidated by ligand docking and molecular dynamics simulations
Y Zhang, G Zheng, T Fu, J Hong, F Li, X Yao… - Physical Chemistry …, 2020 - pubs.rsc.org
Vilazodone is a novel antidepressant used for the treatment of major depressive disorder
(MDD) with a primary action mechanism of inhibiting the human serotonin reuptake …
(MDD) with a primary action mechanism of inhibiting the human serotonin reuptake …
The high‐energy transition state of the glutamate transporter homologue GltPh
Membrane transporters mediate cellular uptake of nutrients, signaling molecules, and drugs.
Their overall mechanisms are often well understood, but the structural features setting their …
Their overall mechanisms are often well understood, but the structural features setting their …
Investigating the mechanism of sodium binding to SERT using direct simulations
D Szöllősi, T Stockner - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
The serotonin transporter (SERT) terminates neurotransmission by transporting serotonin
from the synapse into the pre-synaptic nerve terminal. Altered SERT function leads to …
from the synapse into the pre-synaptic nerve terminal. Altered SERT function leads to …
Identification of a novel allosteric modulator of the human dopamine transporter
S Aggarwal, X Liu, C Rice, P Menell… - ACS chemical …, 2019 - ACS Publications
The dopamine transporter (DAT) serves a pivotal role in controlling dopamine (DA)-
mediated neurotransmission by clearing DA from synaptic and perisynaptic spaces and …
mediated neurotransmission by clearing DA from synaptic and perisynaptic spaces and …
A role for fragment-based drug design in developing novel lead compounds for central nervous system targets
MJ Wasko, KA Pellegrene, JD Madura… - Frontiers in …, 2015 - frontiersin.org
Hundreds of millions of US dollars are invested in the research and development of a single
drug. Lead compound development is an area ripe for new design strategies. Therapeutic …
drug. Lead compound development is an area ripe for new design strategies. Therapeutic …
Butyrate acts as a positive allosteric modulator of the 5‐HT transporter to decrease availability of 5‐HT in the ileum
J Cai, J Cheung, SWM Cheung… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose Radiation therapy‐induced gastrointestinal distress is partly
associated with the elimination of gut microbiota. The effectiveness of 5‐HT receptor …
associated with the elimination of gut microbiota. The effectiveness of 5‐HT receptor …