Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

Besides their role in cell metabolism, mitochondria display many other functions.
Mitochondrial DNA (mtDNA), the own genome of the organelle, plays an important role in …

NLRP3 inflammasome activation is a highly regulated process for controlling secretion of the
potent inflammatory cytokines IL-1β and IL-18 that are essential during bacterial infection …

Calcium is used in many cellular processes and is maintained within the cell as free calcium
at low concentrations (approximately 100 nM), compared with extracellular (millimolar) …

Mitochondria are best known for harboring pathways involved in ATP synthesis through the
tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding …

Uric acid is a damage-associated molecular pattern (DAMP), released from ischemic tissues
and dying cells which, when crystalized, is able to activate the NLRP3 inflammasome …

The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

Calcium (Ca 2+) is considered one of the most-important biological cations, because it is
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …

Mitochondria are key decoding stations of the apoptotic process. In support of this view, a
large body of experimental evidence has unambiguously revealed that, in addition to the …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …