Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

For many years, it was thought that ATG5 and ATG7 played a pivotal role in autophagy, and
that the knockdown of one of these genes would result in its inhibition. However, cells with …

ATG5 is a part of the E3 ligase directing lipidation of ATG8 proteins, a process central to
membrane atg8ylation and canonical autophagy. Loss of Atg5 in myeloid cells causes early …

Aging is associated with impairment of multiple organs, including skeletal muscle and heart.
In this study, we investigated whether resveratrol, an activator of an NAD+-dependent …

Crizotinib, a small-molecule tyrosine kinase inhibitor targeting ALK, MET and ROS1, is the
first-line drug for ALK-positive metastatic non-small cell lung cancer and is associated with …

To investigate the crosstalk of mitochondria associated membranes (MAMs) disorder and
autophagy co-induced by molybdenum (Mo) and cadmium (Cd) in sheep hearts. A total of …

Sustained cardiac hypertrophy damages the heart and weakens cardiac function, often
leading to heart failure and even death. Pathological cardiac hypertrophy has become a …

Nicotinamide adenine dinucleotide (NAD+) is an essential and pleiotropic coenzyme
involved not only in cellular energy metabolism, but also in cell signaling, epigenetic …

An increasing number of individuals are at high risk of type 2 diabetes (T2D) and its
cardiovascular complications, including heart failure (HF), chronic kidney disease (CKD) …

Cardiac hypertrophy is an adaptive response to increased overload, which is induced by
various physiological or pathological stimuli. It is a common pathological process of a variety …