After injury to the adult central nervous system (CNS), injured axons cannot regenerate past
the lesion. In this review, we present evidence that this is due to the formation of a glial scar …

Damage to the adult CNS often leads to persistent deficits due to the inability of mature
axons to regenerate after injury. Mounting evidence suggests that the glial environment of …

▪ Abstract Nerve regeneration is a complex biological phenomenon. In the peripheral
nervous system, nerves can regenerate on their own if injuries are small. Larger injuries …

Golgi ranked the peripheral reticulum—which adheres intimately to nerve cell surfaces—
alongside the intracellular reticulum, or Golgi apparatus, which immortalized his name. At …

Following a previous description of nociceptive nerve fibre growth into usually aneural inner
parts of painful intervertebral disc (IVD), this study has investigated whether nociceptive …

The lack of axonal regeneration in the injured adult mammalian spinal cord leads to
permanent functional impairment. To induce axonal regeneration in the transected adult rat …

Following spinal cord injury, axons fail to regenerate without exogenous intervention. In this
study we report that aligned microfiber-based grafts foster robust regeneration of …

There are now numerous preclinical reports of various experimental treatments promoting
some functional recovery after spinal cord injury. Surprisingly, perhaps, the mechanisms that …

Rubrospinal neurons (RSNs) undergo a marked atrophy in the second week after cervical
axotomy. This delayed atrophy is accompanied by a decline in the expression of …

Adult mammalian CNS neurons do not normally regenerate their severed axons. This failure
has been attributed to scar tissue and inhibitory molecules at the injury site that block the …