Myocardial ischemia is a disease with high morbidity and mortality, for which reperfusion is
currently the standard intervention. However, the reperfusion may lead to further myocardial …

Autophagy is a lysosomal degradation process and protective housekeeping mechanism to
eliminate damaged organelles, long-lived misfolded proteins and invading pathogens …

Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon,
inevitable in kidney transplantation and one of the most important mechanisms for non-or …

Curcumin, a polyphenolic compound extracted from Curcuma longa, has drawn attention for
its effective bioactivities against ischemia-induced injury. This study aimed to evaluate the …

Abstract Ischemia/reperfusion (I/R) of the heart leads to increased autophagic flux.
Preconditioning stimulates autophagic flux by AMPK and PI3-kinase activation and mTOR …

Autophagy mediates cellular quality control mechanisms and energy homeostasis through
lysosomal degradation. Autophagy is typically viewed as an adaptive process that allows …

It has been established that the key metabolic pathways of glycolysis and oxidative
phosphorylation are intimately related to redox biology through control of cell signaling …

Ischemic stroke is one of the leading causes of death and also a major cause of adult
disability worldwide. Revascularization via reperfusion therapy is currently a standard …

Doxorubicin (DOX) is widely used for treating human cancers, but can induce heart failure
through an undefined mechanism. Herein we describe a previously unidentified signaling …

Each cell is equipped with a conserved housekeeping mechanism, known as autophagy, to
recycle exhausted materials and dispose of injured organelles via lysosomal degradation …