Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

The burden of multidrug resistance in Gram-negative bacilli (GNB) now represents a daily
issue for the management of antimicrobial therapy in intensive care unit (ICU) patients. In …

Scope The aim of these guidelines is to provide recommendations for decolonizing
regimens targeting multidrug-resistant Gram-negative bacteria (MDR-GNB) carriers in all …

Introduction: Management of antimicrobial resistance in multi-drug-resistant-Klebsiella
pneumoniae (MDR-KP) is a major challenge for clinicians. The optimal treatment option for …

abstract Bloodstream infections (BSI) are among the most frequent complications in
neutropenic cancer patients and, if caused by Gram-negative rods, are associated with high …

Introduced in the 1980s, carbapenem antibiotics have served as the last line of defense
against multidrug‐resistant Gram‐negative organisms. Over the last decade, carbapenem …

Background Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-
KP) has become one of the most important contemporary pathogens, especially in endemic …

The clinical impact of infections due to extended-spectrum β-lactamase (ESBL)-and/or
carbapenemase-producing Enterobacterales (Ent) has reached dramatic levels worldwide …

Background ESBL-producing Enterobacteriaceae and carbapenem-resistant
Enterobacteriaceae (CRE) are rapidly spreading worldwide. Their natural reservoir is …

In this review, we provide an updated summary on colistin pharmacokinetics and
pharmacodynamics. Colistin is an old molecule that is frequently used as last-line treatment …