atherosclerosis, hypertension, cardiac hypertrophy and remodeling, angiogenesis and
collateral formation, stroke, and heart failure. In this review, we discuss in detail the …

NADPH oxidases of the Nox family exist in various supergroups of eukaryotes but not in
prokaryotes, and play crucial roles in a variety of biological processes, such as host defense …

▪ Abstract Research in the past decade has revealed that many cytosolic proteins are
recruited to different cellular membranes to form protein-protein and lipid-protein interactions …

The NADPH oxidase of professional phagocytes is a crucial component of the innate
immune response due to its fundamental role in the production of reactive oxygen species …

Phox homology (PX) domains are membrane interacting domains that bind to
phosphatidylinositol phospholipids or phosphoinositides, markers of organelle identity in the …

Neutrophils play an essential role in the body's innate defense against pathogens and are
one of the primary mediators of the inflammatory response. To defend the host, neutrophils …

Sorting nexins are a diverse group of cellular trafficking proteins that are unified by the
presence of a phospholipid-binding motif—the PX domain. The ability of these proteins to …

The reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is part of the
microbicidal arsenal used by human polymorphonuclear neutrophils (PMNs) to eradicate …

Phosphatidylinositolphosphates (PIP s) are phospholipids that contain a phosphorylated
inositol head group. PIP s represent a minor fraction of total phospholipids, but are involved …

Stimulated phagocytes undergo a burst in respiration whereby molecular oxygen is
converted to superoxide anion through the action of an NADPH-dependent oxidase. The …