The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

A growing body of research is investigating the potential contribution of mitochondrial
function to the etiology of type 2 diabetes. Numerous in vitro, in situ, and in vivo …

Abstract Background The Study of Muscle, Mobility and Aging (SOMMA) aims to understand
the biological basis of many facets of human aging, with a focus on mobility decline, by …

Extensively revised, the fourth edition of this highly successful book takes into account the
many newly determined protein structures that provide molecular insight into chemiosmotic …

Background. Lower ambulatory performance with aging may be related to a reduced
oxidative capacity within skeletal muscle. This study examined the associations between …

Background Mitochondrial energetics are an important property of aging muscle, as
generation of energy is pivotal to the execution of muscle contraction. However, its …

In almost all eukaryotic cells, mitochondria provide the vast majority of the ATP required to
maintain viability and to execute all cellular functions such as muscle contraction …

The maintenance of functional independence is the top priority of patients with chronic
kidney disease (CKD). Defects in mitochondrial energetics may compromise physical …

The goal of this study is to identify a signature of bioenergetic and functional markers in the
muscles of individuals with Parkinson's disease (PD). Quantitative physiological properties …

Background: Aerobic fitness and muscle bioenergetic capacity decline with age; whether
such declines explain age-related slowing of walking speed is unclear. We hypothesized …