Viperin reveals its true function
EE Rivera-Serrano, AS Gizzi, JJ Arnold… - Annual review of …, 2020 - annualreviews.org
Most cells respond to viral infections by activating innate immune pathways that lead to the
induction of antiviral restriction factors. One such factor, viperin, was discovered almost two …
induction of antiviral restriction factors. One such factor, viperin, was discovered almost two …
The emerging roles of IFIT3 in antiviral innate immunity and cellular biology
W Zhang, Y Li, S Xin, L Yang, M Jiang… - Journal of medical …, 2023 - Wiley Online Library
The interferon‐inducible protein with tetrapeptide repeats 3 (IFIT3) is one of the most
important members in both the IFIT family and interferon‐stimulated genes family. IFIT3 has …
important members in both the IFIT family and interferon‐stimulated genes family. IFIT3 has …
Human airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variants
The high transmissibility of SARS-CoV-2 Omicron subvariants was generally ascribed to
immune escape. It remained unclear whether the emerging variants have gradually …
immune escape. It remained unclear whether the emerging variants have gradually …
[HTML][HTML] Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses
Nucleic acids are powerful triggers of innate immunity and can adopt the Z-conformation, an
unusual left-handed double helix. Here, we studied the biological function (s) of Z-RNA …
unusual left-handed double helix. Here, we studied the biological function (s) of Z-RNA …
[HTML][HTML] Translation stress and collided ribosomes are co-activators of cGAS
The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway
senses cytosolic DNA and induces interferon-stimulated genes (ISGs) to activate the innate …
senses cytosolic DNA and induces interferon-stimulated genes (ISGs) to activate the innate …
The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells
Methylguanosine 5′ cap on mRNA is necessary for efficient protein expression in vitro and
in vivo. Recent studies revealed structural diversity of endogenous mRNA caps, which carry …
in vivo. Recent studies revealed structural diversity of endogenous mRNA caps, which carry …
[HTML][HTML] Asymptomatic infection of Marburg virus reservoir bats is explained by a strategy of immunoprotective disease tolerance
Marburg virus (MARV) is among the most virulent pathogens of primates, including humans.
Contributors to severe MARV disease include immune response suppression and …
Contributors to severe MARV disease include immune response suppression and …
[HTML][HTML] Modulation of extracellular ISG15 signaling by pathogens and viral effector proteins
ISG15 is a ubiquitin-like modifier that also functions extracellularly, signaling through the
LFA-1 integrin to promote interferon (IFN)-γ release from natural killer (NK) and T cells. The …
LFA-1 integrin to promote interferon (IFN)-γ release from natural killer (NK) and T cells. The …
Type I interferon signaling, regulation and gene stimulation in chronic virus infection
S Lukhele, GM Boukhaled, DG Brooks - Seminars in immunology, 2019 - Elsevier
Abstract Type I Interferons (IFN-I) mediate numerous immune interactions during viral
infections, from the establishment of an antiviral state to invoking and regulating innate and …
infections, from the establishment of an antiviral state to invoking and regulating innate and …
[HTML][HTML] The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent
S Skopelja-Gardner, J An, J Tai, L Tanaka, X Sun… - Scientific reports, 2020 - nature.com
Most systemic lupus erythematosus (SLE) patients are photosensitive and ultraviolet B light
(UVB) exposure worsens cutaneous disease and precipitates systemic flares of disease …
(UVB) exposure worsens cutaneous disease and precipitates systemic flares of disease …