The skin barrier is broadly composed of two elements—a physical barrier mostly localised in
the epidermis, and an immune barrier localised in both the dermis and epidermis. These two …

The observed incidence of psoriasis has been gradually increasing over time (J Am Acad
Dermatol, 03, 2009, 394), but the underlying pathogenic factors have remained unclear …

The disease-residual transcriptomic profile (DRTP) within psoriatic healed/resolved skin and
epidermal tissue-resident memory T (TRM) cells have been proposed to be crucial for the …

Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease and
clinically manifests with cognitive decline and behavioral disabilities. Over the past years …

Background Numerous alterations in gene expression have been described in psoriatic
lesions compared to uninvolved or healthy skin. However, the mechanisms which induce …

Continuous exposure of the skin to environmental, mechanical and chemical stress
necessitates constant self‐renewal of the epidermis to maintain its barrier function. This self …

Transglutaminase 3 (TGM3) protects against skin inflammation in psoriasis, but the precise
role and mechanism of action of TGM3 in the pathogenesis of psoriasis remain unclear. In …

DNA methylation is a key regulatory event controlling a variety of physiological processes
and can have dramatic effects on gene transcription. Methylated cytosine (5-methylcytosine) …

Relative to conventional two-dimensional (2-D) culture, three-dimensional (3-D) suspension
culture of epithelial cells more closely mimics the in vivo cell microenvironment regarding …

Keratinocytes are one of the primary cells affected by psoriasis inflammation. Our study
aimed to delve deeper into their morphology, transcriptome, and epigenome changes in …