To bridge the gap between organ demand and supply, xenotransplantation has long been
considered as a realistic option for end-stage organ failure. Early this year this promise …

In pigs, the major histocompatibility complex (MHC), or swine leukocyte antigen (SLA)
complex, maps to Sus scrofa chromosome 7. It consists of three regions, the class I and …

Abstract Purpose of Review Porcine islets represent a potentially attractive beta-cell source
for xenotransplantation into patients with type 1 diabetes, who are not eligible to islet allo …

The extreme shortage of human donor organs for treatment of patients with end-stage organ
failures is well known. Xenotransplantation, which might provide unlimited organ supply, is a …

Meeting the increasing demands for high-quality pork protein requires not only improved
diets but also biotechnology-based breeding to generate swine with desired production …

Pig liver xenotransplantation appears to be more perplexing when compared to heart or
kidney xenotransplantation, even though great progress has been achieved. The relevant …

Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (CRISPR/Cas9) genome editing technology has dramatically influenced swine …

Newly emerging technologies are rapidly changing conventional approaches to organ
transplantation. In the modern era, the key challenges to transplantation include (1) how to …

The efforts to overcome the natural antibody response to xenoantigens are largely sufficient.
There is great opportunity for designing immunosuppression protocols and for detecting …

Background Differences in quality and strength of immune responses between individuals
are mainly due to polymorphisms in major histocompatibility complex (MHC) molecules …