Leishmaniasis and Chagas disease chemotherapy: a critical review

I Silva-Jardim, OH Thiemann, FF Anibal - Journal of the Brazilian …, 2014 - SciELO Brasil
Leishmaniasis and Chagas disease, caused by the kinetoplastid parasites Leishmania spp
and Trypanosoma cruzi, respectively, are among the most important parasitic diseases …

[HTML][HTML] Niosomal formulation of amphotericin B alone and in combination with glucantime: In vitro and in vivo leishmanicidal effects

M Mostafavi, I Sharifi, S Farajzadeh, P Khazaeli… - Biomedicine & …, 2019 - Elsevier
This study aimed to evaluate the efficacy of glucantime and amphotericin B (AmB)
encapsulated in niosome against cutaneous leishmaniasis (CL) using in vitro and in vivo …

Meglumine antimoniate is more effective than sodium stibogluconate in the treatment of cutaneous leishmaniasis

Y Yesilova, HA Surucu, N Ardic, M Aksoy… - Journal of …, 2016 - Taylor & Francis
Sodium stibogluconate (SSG, Pentostam) and meglumine antimoniate (MA, Glucantime) are
two antimonials that are widely used to treat cutaneous leishmaniasis (CL), but the relative …

Leishmanicidal effects of amphotericin B in combination with selenium loaded on niosome against Leishmania tropica

M Mostafavi, S Farajzadeh, I Sharifi, P Khazaeli… - Journal of Parasitic …, 2019 - Springer
The strategy for improving the treatment of leishmaniasis by the World Health Organization,
is the development of new drugs and combination therapy. The aim of this survey was to …

Leishmaniasis: history, evolution of treatment and the need for new drugs

E Azevedo Cardoso, A Rodrigues da Silva… - Current …, 2014 - ingentaconnect.com
Leishmaniasis is defined as a cluster of infectious diseases caused by protozoan parasites
of the genus Leishmania. It is recognized worldwide as a major health problem, showing …

[HTML][HTML] A novel niosomal combination of selenium coupled with glucantime against Leishmania tropica

M Mostafavi, P Khazaeli, I Sharifi… - The Korean journal of …, 2019 - ncbi.nlm.nih.gov
There is no effective treatment modality available against different forms of leishmaniasis.
Therefore, the aim of this study was to improve the penetration and efficacy of selenium and …

Ursolic acid potentializes conventional therapy in experimental leishmaniasis

JA Jesus, TN Fragoso da Silva, ES Yamamoto… - Pathogens, 2020 - mdpi.com
Ursolic acid (UA) is a triterpene with a broad array of pharmacological activities. In
leishmaniasis, UA killed different species of parasites, and it was active in the experimental …

The Effects of Polyhexamethylene Biguanide (PHMB) and TLR Agonists Alone or as Polyplex Nanoparticles against Leishmania infantum Promastigotes and …

P Martínez-Orellana, M Baxarias, L Good… - Veterinary …, 2020 - mdpi.com
Dogs are the main reservoir for Leishmania infantum, manifesting from a subclinical to a
fatal disease. Limited treatments are available, although new antiparasitics and …

Overcoming the Challenge; In Vivo Efficacy of Miltefosine for Chronic Cutaneous Leishmaniasis

V Tunalı, M Harman, İ Çavuş, C Gündüz, A Özbilgin… - Acta Parasitologica, 2021 - Springer
Abstract Background Cutaneous Leishmaniasis (CL) is the most common form of
leishmaniasis. CL can be divided into two major groups: acute CL (ACL) and chronic CL …

[HTML][HTML] A novel strategy for enhance potentiation of meglumine antimoniate against Leishmania major in vitro

F Mirzaei, H Khanahmad, F Namdar… - Iranian Journal of …, 2019 - ncbi.nlm.nih.gov
Background: We aimed to design a different method of drug delivery for increased transfer of
the choice drug (meglumine antimoniate) within the host cells. Therefore, listeriolysin O …