The complement system plays critical roles in development, homeostasis, and regeneration
in the central nervous system (CNS) throughout life; however, complement dysregulation in …

Since the discovery of dopamine as a neurotransmitter in the 1950s, P arkinson's disease
(PD) research has generated a rich and complex body of knowledge, revealing PD to be an …

Previous studies demonstrate that intrastriatal injections of fibrillar alpha-synuclein (α-syn)
into mice induce Parkinson's disease (PD)-like Lewy body (LB) pathology formed by …

Parkinson's disease (PD) is a complex disease, with genetics and environment contributing
to the disease onset. Recent studies of causative PD genes have confirmed the involvement …

Parkinson's disease (PD) has classically been defined as a movement disorder, in which
motor symptoms are explained by the aggregation of alpha-synuclein (α-syn) and …

Parkinson's disease (PD) is a progressive neurodegenerative disorder whose etiology,
besides a minority of genetic cases, is still largely unknown. Animal models have contributed …

Our study utilizes a longitudinal isotopic metabolic labeling approach in vivo in combination
with organelle fraction proteomics to address the role of parkin in mitochondrial protein …

Preclinical research on Parkinson's disease has relied heavily on mouse and rat animal
models. Initially, PD animal models were generated primarily by chemical neurotoxins that …

Parkinson's disease (PD) is a movement disorder caused by neurodegeneration in
neocortex, substantia nigra and brainstem, and synucleinopathy. Some inherited PD is …

Microglia are the specialized macrophages of the central nervous system and play an
important role in neural circuit development, modulating neurotransmission, and maintaining …