The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

Hypoxia‐mimetic agents are new potential tools in MSC priming instead of hypoxia
incubators or chambers. Several pharmaceutical/chemical hypoxia‐mimetic agents can be …

Wound healing is a serious obstacle due to the complexity of evaluation and management.
While novel approaches to promoting chronic wound healing are of critical interest at the …

Inflammation is a common complication of many chronic diseases. It includes inflammation
of the parenchyma and vascular systems. Sirtuin 1 (SIRT1) is a nicotinamide adenine …

Mesenchymal stem cells (MSCs) are located in various tissues where these cells show
niche‐dependent multilineage differentiation and secrete immunomodulatory molecules to …

Animal model studies and first clinical trials have demonstrated the safety and efficacy of the
mesenchymal stem cells'(MSCs) transplantation in stroke. Intra-arterial (IA) administration …

Liver diseases with different pathogenesis share common pathways of immune-mediated
injury. Chitinase-3-like protein 1 (CHI3L1) was induced in both acute and chronic liver …

Liver diseases, characterized by high morbidity and mortality, represent a substantial
medical problem globally. The current therapeutic approaches are mainly aimed at reducing …

Both platelets and the liver play important roles in the processes of coagulation and innate
immunity. Platelet responses at the site of an injury are rapid; their immediate activation and …

Overall, the human organism requires the production of∼ 1 trillion new blood cells per day.
Such goal is achieved via hematopoiesis occurring within the bone marrow (BM) under the …