The fission yeast Schizosaccharomyces pombe is an important model organism for the study
of eukaryotic molecular and cellular biology. Studies of S. pombe, together with studies of its …

Meiosis halves diploid chromosome numbers to haploid levels that are essential for sexual
reproduction in most eukaryotes. Meiotic recombination ensures the formation of bivalents …

Abstract Heterochromatin protein 1 (HP1) is localized at heterochromatin sites where it
mediates gene silencing,. The chromo domain of HP1 is necessary for both targeting and …

Loss of telomere function can induce cell cycle arrest and apoptosis. To investigate the
processes that trigger cellular responses to telomere dysfunction, we crossed mTR−/− G6 …

It has been puzzling that mammalian telomeric proteins, including TRF1, TRF2, tankyrase,
and TIN2 have no recognized orthologs in budding yeast. Here, we describe a human …

Homologous recombination is essential during meiosis in most sexually reproducing
organisms. In budding yeast, and most likely in other organisms as well, meiotic …

In yeast, telomere position effect (TPE) results in the reversible silencing of genes near
telomeres. Here we demonstrate the presence of TPE in human cells. HeLa clones …

Histone lysine methylation is a key regulator of gene expression and heterochromatin
function, but little is known as to how this modification impinges on other chromatin activities …

▪ Abstract The leptotene/zygotene transition of meiosis, as defined by classical cytological
studies, is the period when homologous chromosomes, already being discernible …

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