ABSTRACT ATM and ATR signaling pathways are well conserved throughout evolution and
are central to the maintenance of genome integrity. Although the role of both ATM and ATR …

Maintenance of genome stability is essential for avoiding the passage to neoplasia. The
DNA-damage response—a cornerstone of genome stability—occurs by a swift transduction …

The normal functioning of p53 is a potent barrier to cancer. Tumour-associated mutations in
TP53, typically single nucleotide substitutions in the coding sequence, are a hallmark of …

S2 cancer in the general population remains unclear. Furthermore, the methodology of ATM
mutation detection is still laborious and costly. Because the ATM protein kinase …

Mutations in the isocitrate dehydrogenase-1 gene (IDH1) are common drivers of acute
myeloid leukemia (AML) but their mechanism is not fully understood. It is thought that IDH1 …

The complex containing the Mre11, Rad50, and Nbs1 proteins (MRN) is essential for the
cellular response to DNA double-strand breaks, integrating DNA repair with the activation of …

The DNA damage response enables cells to cope with various stresses that threaten
genomic integrity. A critical component of this response is the serine/threonine kinase CHK1 …

Breast and ovarian cancers are among the most common cancers in women. It is known that
a woman is at higher risk for breast or ovarian cancer if a family member has had the …

Haploinsufficiency is defined as a dominant phenotype in diploid organisms that are
heterozygous for a loss-of-function allele. Despite its relevance to human disease, neither …

DNA damage, especially DNA double strand breaks (DSBs) and replication stress, activates
a complex post-translational network termed DNA damage response (DDR). Our review …