The current research paradigm for Huntington's disease is based on participants with overt
clinical phenotypes and does not address its pathophysiology nor the biomarker changes …

A caregiver's all‐too‐familiar narrative‐“He doesn't think through what he does, but mostly
he does nothing.” Apathy and impulsivity, debilitating and poorly understood, commonly co …

Background An increased risk of suicide in Huntington's disease (HD) patients is well
documented, with rates significantly higher than those of the general population as well as …

We investigated the effects of transcranial alternating current stimulation (tACS) targeted to
the bilateral medial prefrontal cortex (mPFC) and administered at either delta or alpha …

A reduction in goal-directed behavior, or apathy, occurs in neurological and psychiatric
disorders, though its neural substrates remain unclear. Deficits in circuits connecting the …

BackgroundCognitive impairment is a core feature of Huntington's disease (HD), however,
the onset and rate of cognitive decline is highly variable. Apathy is the most common …

The gating of movement depends on activity within the cortico-striato-thalamic loops. Within
these loops, emerging from the cells of the striatum, run two opponent pathways—the direct …

Objective: Apathy is a common behavioral symptom of Huntington disease (HD). This
systematic review describes current evidence on the pathophysiology, assessment, and …

Background/aims The presence of non-motor symptoms in Huntington's disease (HD) has
not been systematically assessed so far. Our objective was to know their prevalence and to …

Background Apathy is the neuropsychiatric syndrome that correlates most highly with
Huntington's disease progression, and, like early patterns of neurodegeneration, is …