Republished: Basic science behind the cardiovascular benefits of exercise

MG Wilson, GM Ellison, NT Cable - Postgraduate Medical …, 2015 - academic.oup.com
Cardiorespiratory fitness is a strong predictor of cardiovascular (CV) disease and all-cause
mortality, with increases in cardiorespiratory fitness associated with corresponding …

Cell therapy for cardiac repair—lessons from clinical trials

A Behfar, R Crespo-Diaz, A Terzic… - Nature Reviews …, 2014 - nature.com
The global impetus to identify curative therapies has been fuelled by the unmet needs of
patients in the context of a growing heart failure pandemic. To date, regeneration trials in …

Aged‐senescent cells contribute to impaired heart regeneration

FC Lewis‐McDougall, PJ Ruchaya… - Aging cell, 2019 - Wiley Online Library
Aging leads to increased cellular senescence and is associated with decreased potency of
tissue‐specific stem/progenitor cells. Here, we have done an extensive analysis of cardiac …

[HTML][HTML] Adult c-kitpos cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair

GM Ellison, C Vicinanza, AJ Smith, I Aquila, A Leone… - Cell, 2013 - cell.com
The epidemic of heart failure has stimulated interest in understanding cardiac regeneration.
Evidence has been reported supporting regeneration via transplantation of multiple cell …

A fast pH‐switchable and self‐healing supramolecular hydrogel carrier for guided, local catheter injection in the infarcted myocardium

MMC Bastings, S Koudstaal, RE Kieltyka… - Advanced …, 2014 - Wiley Online Library
Minimally invasive intervention strategies after myocardial infarction use state‐of‐the‐art
catheter systems that are able to combine mapping of the infarcted area with precise, local …

Stem cell therapy: a new therapeutic option for cardiovascular diseases

NH Goradel, FG Hour, B Negahdari… - Journal of cellular …, 2018 - Wiley Online Library
Cardiovascular diseases are known as one of major causes of morbidity and mortality
worldwide. Despite the many advancement in therapies are associated with cardiovascular …

[HTML][HTML] Drug and cell delivery for cardiac regeneration

CL Hastings, ET Roche, E Ruiz-Hernandez… - Advanced drug delivery …, 2015 - Elsevier
The spectrum of ischaemic cardiomyopathy, encompassing acute myocardial infarction to
congestive heart failure is a significant clinical issue in the modern era. This group of …

Current applications of polycaprolactone as a scaffold material for heart regeneration

PR Schmitt, KD Dwyer… - ACS Applied Bio Materials, 2022 - ACS Publications
Despite numerous advances in treatments for cardiovascular disease, heart failure (HF)
remains the leading cause of death worldwide. A significant factor contributing to the …

Doxorubicin targets multiple players: a new view of an old problem

D Cappetta, F Rossi, E Piegari, F Quaini… - Pharmacological …, 2018 - Elsevier
Anthracycline cardiotoxicity remains a serious problem in paediatric and adult cancer
survivors, and the advancement of cardio-oncology is a necessary step for an effective care …

Human amnion-derived mesenchymal stem cell (hAD-MSC) transplantation improves ovarian function in rats with premature ovarian insufficiency (POI) at least partly …

L Ling, X Feng, T Wei, Y Wang, Y Wang… - Stem cell research & …, 2019 - Springer
Background Chemotherapy can induce premature ovarian insufficiency (POI) and reduce
fertility in young female patients. Currently, there is no effective therapy for POI. Human …