Nickel carcinogenesis mechanism: DNA damage

H Guo, H Liu, H Wu, H Cui, J Fang, Z Zuo… - International journal of …, 2019 - mdpi.com
Nickel (Ni) is known to be a major carcinogenic heavy metal. Occupational and
environmental exposure to Ni has been implicated in human lung and nasal cancers …

Transition metal salen complexes in bioinorganic and medicinal chemistry

A Erxleben - Inorganica Chimica Acta, 2018 - Elsevier
Salen is a common abbreviation for tetradentate N 2 O 2 bis-Schiff base bis-phenolate
ligands. Due to the ease of their synthesis, rich coordination chemistry and photophysical …

Novel Bromo and methoxy substituted Schiff base complexes of Mn (II), Fe (III), and Cr (III) for anticancer, antimicrobial, docking, and ADMET studies

LH Abdel-Rahman, AA Abdelghani, AA AlObaid… - Scientific reports, 2023 - nature.com
In this study, four new Mn (II), Fe (III), and Cr (III) complexes with two Schiff base ligands
namely, 4-bromo-2-[(E)-{[4-(2-hydroxyethyl) phenyl] imino} methyl] phenol (HL1) and 2-[(E) …

Mechanism of effects of nickel or nickel compounds on intestinal mucosal barrier

L Huang, F He, B Wu - Chemosphere, 2022 - Elsevier
As an important metal in industry, national defense, and production, nickel widely exists in
nature and is also a necessary trace element for human beings and animals. Nickel …

On the Mechanism of Gold/NHC Compounds Binding to DNA G‐Quadruplexes: Combined Metadynamics and Biophysical Methods

D Wragg, A De Almeida, R Bonsignore… - Angewandte …, 2018 - Wiley Online Library
The binding modes and free‐energy landscape of two AuI/N‐heterocyclic carbene
complexes interacting with G‐quadruplexes, namely a human telomeric (hTelo) and a …

New insights on the interaction of phenanthroline based ligands and metal complexes and polyoxometalates with duplex DNA and G-quadruplexes

Á Sánchez-González, NAG Bandeira… - Molecules, 2021 - mdpi.com
This work provides new insights from our team regarding advances in targeting canonical
and non-canonical nucleic acid structures. This modality of medical treatment is used as a …

On the binding modes of metal NHC complexes with DNA secondary structures: implications for therapy and imaging

Ö Karaca, SM Meier-Menches, A Casini… - Chemical …, 2017 - pubs.rsc.org
Organometallic compounds currently occupy an important place in the field of medicinal
inorganic chemistry due to the unique chemical properties of metal coordination …

Learning to model G-quadruplexes: current methods and perspectives

I Ortiz de Luzuriaga, X Lopez… - Annual Review of …, 2021 - annualreviews.org
G-quadruplexes have raised considerable interest during the past years for the development
of therapies against cancer. These noncanonical structures of DNA may be found in …

Nickel carcinogenesis mechanism: cell cycle dysregulation

H Guo, H Deng, H Liu, Z Jian, H Cui, J Fang… - … Science and Pollution …, 2021 - Springer
Nickel (Ni) is a widely distributed metal in the environment and an important pollutant due to
its widespread industrial applications. Ni has various toxicity in humans and experimental …

Comparative biological evaluation and G-quadruplex interaction studies of two new families of organometallic gold (I) complexes featuring N-heterocyclic carbene and …

SM Meier-Menches, B Aikman, D Döllerer… - Journal of Inorganic …, 2020 - Elsevier
Experimental organometallic gold (I) compounds hold promise for anticancer therapy. This
study reports the synthesis of two novel families of gold (I) complexes, including N1 …