As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of
cellular processes, including cell polarity, cell migration, and cell cycle progression. The …

Calcium is a versatile element that participates in cell signaling for a wide range of cell
processes such as death, cell cycle, division, migration, invasion, metabolism, differentiation …

The identification of colorectal cancer (CRC) molecular targets is needed for the
development of drugs that improve patient survival. We investigated the functional role of …

Blood–tumor barrier (BTB) presents a major obstacle to brain drug delivery. Therefore, it is
urgent to enhance BTB permeability for the treatment of glioma. In this study, we …

Most human cancers arise from epithelial tissues, which are apical-basally polarized and
possess intercellular adhesive junctions. Epithelial cells grow to characteristic densities …

The apical junctional complex (AJC) is a cell-cell adhesion system present at the upper
portion of the lateral membrane of epithelial cells integrated by the tight junction (TJ) and the …

Background: Metastasis is often derived from increased invasion and migration of tumor
cells, and is the most frequent cause of cancer-associated death. Either the prophylactic or …

The key molecular mechanism governing the cancer cell state (stem cell-like state vs
differentiation state) to control the cancer stem cell (CSC) pool remains elusive. This study …

Simple Summary HPV+ and HPV-HNSCC share distinct epigenetic characteristics and
clinicopathological features. The aim of our study was to assess whether DNA methylation …

Background Like other human cancers, the malignancy of cervical cancer is also
characterized by abilities of proliferation, migration, and invasion. Protein kinase C-zeta …