Progress in target drug molecules for Alzheimer's disease
J Xie, R Liang, Y Wang, J Huang… - Current Topics in …, 2020 - ingentaconnect.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease that 4 widespread in the
elderly. The etiology of AD is complicated, and its pathogenesis is still unclear. Although …
elderly. The etiology of AD is complicated, and its pathogenesis is still unclear. Although …
[HTML][HTML] Role of GSK-3β inhibitors: new promises and opportunities for Alzheimer's disease
SR Shri, S Manandhar, Y Nayak… - Advanced Pharmaceutical …, 2023 - ncbi.nlm.nih.gov
Abstract Glycogen synthase kinase-3 (GSK-3) was discovered to be a multifunctional
enzyme involved in a wide variety of biological processes, including early embryo formation …
enzyme involved in a wide variety of biological processes, including early embryo formation …
Molecular docking, molecular dynamics, MM/PBSA approaches and bioactivity studies of nepetanudoside B isolated from endemic Nepeta aristata
Nepetanudoside B (NNB) was isolated from aerial parts of endemic Nepeta aristata crude
extract (CH3OH-CHCl3) using silica gel (n-hexane, methanol, ethyl acetate, and …
extract (CH3OH-CHCl3) using silica gel (n-hexane, methanol, ethyl acetate, and …
Synthesis and anticancer evaluation of some new pyrazolo[3,4‐d][1,2,3]triazin‐4‐ones, pyrazolo[1,5‐a]pyrimidines, and imidazo[1,2‐b]pyrazoles clubbed with …
S Bondock, S Alqahtani… - Journal of Heterocyclic …, 2021 - Wiley Online Library
Carbazole represents as a promising template for cancer treatment as it exists in the
skeleton of numerous man‐made and natural anticancer agents. In this regard, new sets of …
skeleton of numerous man‐made and natural anticancer agents. In this regard, new sets of …
Preparation of Novel Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides and Their Experimental and Computational Biological Studies
Pyrazolo [4, 3-e] tetrazolo [1, 5-b][1, 2, 4] triazine sulfonamides constitute a novel class of
heterocyclic compounds with broad biological activity, including anticancer properties …
heterocyclic compounds with broad biological activity, including anticancer properties …
Genistein and Galantamine Combinations Decrease β-Amyloid Peptide (1–42)–Induced Genotoxicity and Cell Death in SH-SY5Y Cell Line: an In Vitro and In Silico …
WO Castillo, NV Palomino, CS Takahashi… - Neurotoxicity …, 2020 - Springer
Alzheimer's disease (AD) is the primary dementia-causing disease worldwide, involving a
multifactorial combination of environmental, genetic, and epigenetic factors, with essential …
multifactorial combination of environmental, genetic, and epigenetic factors, with essential …
Small molecule GSK-3 antagonists play a pivotal role in reducing the local inflammatory response, in promoting resident stem cell activation and in improving tissue …
M Tatullo, I Makeeva, S Rengo, C Rengo… - Histology and …, 2019 - europepmc.org
Regenerative dentistry is attracting growing interest in the scientific community, mainly
because of its translational and promising therapeutic approach. The latest research carried …
because of its translational and promising therapeutic approach. The latest research carried …
Structural investigation of the interaction mechanism between chlorogenic acid and AMPA receptor via in silico approaches
W Zhu, F Wu, J Hu, W Wang, J Zhang, G Guo - Molecules, 2022 - mdpi.com
Chlorogenic acid (CGA), an important metabolite in natural plant medicines such as
honeysuckle and eucommia, has been shown to have potent antinociceptive effects …
honeysuckle and eucommia, has been shown to have potent antinociceptive effects …
Theoretical and experimental approaches aimed at drug design targeting neurodegenerative diseases
S Morales-Navarro, L Prent-Peñaloza… - Processes, 2019 - mdpi.com
In recent years, green chemistry has been strengthening, showing how basic and applied
sciences advance globally, protecting the environment and human health. A clear example …
sciences advance globally, protecting the environment and human health. A clear example …
Novel synthesis of new triazine sulfonamides with antitumor, anti-microbial and anti-SARS-CoV-2 activities
RA Mohamed-Ezzat, GH Elgemeie - BMC chemistry, 2024 - Springer
Novel approach for synthesizing triazine sulfonamide derivatives is accomplished via
reacting the sulfaguanidine derivatives with N-cyanodithioiminocarbonate. Further reaction …
reacting the sulfaguanidine derivatives with N-cyanodithioiminocarbonate. Further reaction …