Dynamics of morphogen source formation in a growing tissue
A tight regulation of morphogen production is key for morphogen gradient formation and
thereby for reproducible and organised organ development. Although many genetic …
thereby for reproducible and organised organ development. Although many genetic …
AI-powered simulation-based inference of a genuinely spatial-stochastic gene regulation model of early mouse embryogenesis
MA Ramirez Sierra, TR Sokolowski - PLOS Computational Biology, 2024 - journals.plos.org
Understanding how multicellular organisms reliably orchestrate cell-fate decisions is a
central challenge in developmental biology, particularly in early mammalian development …
central challenge in developmental biology, particularly in early mammalian development …
Stable developmental patterns of gene expression without morphogen gradients
M Majka, NB Becker, PR Ten Wolde… - PLOS Computational …, 2024 - journals.plos.org
Gene expression patterns in developing organisms are established by groups of cross-
regulating target genes that are driven by morphogen gradients. As development …
regulating target genes that are driven by morphogen gradients. As development …