Structural biologists have traditionally approached cellular complexity in a reductionist
manner in which the cellular molecular components are fractionated and purified before …

The nuclear pore complex (NPC) serves as the sole bidirectional gateway of
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …

YAP is a mechanosensitive transcriptional activator with a critical role in cancer,
regeneration, and organ size control. Here, we show that force applied to the nucleus …

Recent advances in cryo-electron microscopy have marked only the beginning of the
potential of this technique. To bring structure into cell biology, the modality of cryo-electron …

Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …

Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport
between the cytoplasm and nucleoplasm. However, their large size and dynamic nature …

Nuclear pore complexes (NPCs) fuse the inner and outer nuclear membranes to form
channels across the nuclear envelope. They are large macromolecular assemblies with a …

Integrative structure determination is a powerful approach to modeling the structures of
biological systems based on data produced by multiple experimental and theoretical …

The application of nanotechnology concepts to medicine joins two large cross‐disciplinary
fields with an unprecedented societal and economical potential arising from the natural …

Nuclear entry of HIV-1 replication complexes through intact nuclear pore complexes is
critical for successful infection. The host protein cleavage-and-polyadenylation-specificity …