In this review, we detail the efforts performed to couple the purification and the
immobilization of industrial enzymes in a single step. The use of antibodies, the …

In the past decade, the asymmetric synthesis of chiral nonracemic isoquinoline alkaloids, a
family of natural products showing a wide range of structural diversity and biological and …

Enzymatic cascade reactions experience tremendous attention by cutting short conventional
step-by-step synthesis in a highly efficient and elegant fashion. Focusing on ω …

Biocatalysis employing imine reductases is a promising approach for the one‐step
generation of chiral amines from ketones. The enzymes reported for this process suffer from …

The Pictet-Spengler reaction (PS) is one of the most direct, efficient, and variable synthetic
method for the construction of privileged pharmacophores such as tetrahydro-isoquinolines …

Imine reductases (IREDs) show great potential as catalysts for reductive amination of
ketones to produce chiral secondary amines. In this work, we explored this potential and …

Protein tyrosine phosphatase 1B (PTP1B) is a crucial therapeutic target for multiple human
diseases comprising type 2 diabetes (T2DM) and obesity because it is a seminal part of a …

The human body is amazingly chirally selective, and consequently enantiopure drugs are
essential for treating disease. Nearly 50% of drugs are chiral wherein pharmacological …

Chiral alcohols are versatile building blocks and are of particular interest in the asymmetric
synthesis of nonracemic active pharmaceutical ingredients, agrochemicals, fragrances …

The efficient asymmetric catalytic synthesis of amines containing more than one stereogenic
center is a current challenge. Here, we present a biocatalytic cascade that combines ene …