Role of oxidative stress in the concurrent development of osteoporosis and tendinopathy: Emerging challenges and prospects for treatment modalities
X Xia, Z Fang, Y Qian, Y Zhou, H Huang… - Journal of Cellular …, 2024 - Wiley Online Library
Both osteoporosis and tendinopathy are widely prevalent disorders, encountered in diverse
medical contexts. Whilst each condition has distinct pathophysiological characteristics, they …
medical contexts. Whilst each condition has distinct pathophysiological characteristics, they …
Cellular senescence impairs tendon extracellular matrix remodeling in response to mechanical unloading
EJ Stowe, MR Keller, BK Connizzo - Aging Cell, 2023 - Wiley Online Library
Musculoskeletal injuries, including tendinopathies, present a significant clinical burden for
aging populations. While the biological drivers of age‐related declines in tendon function …
aging populations. While the biological drivers of age‐related declines in tendon function …
M2 macrophage-derived exosomes promote tendon-to-bone healing by alleviating cellular senescence in aged rats
Z Cai, L Shu, C Wang, X Xie, X Liu - … : The Journal of Arthroscopic & Related …, 2024 - Elsevier
Purpose To explore the potential of M2 macrophage-derived exosomes (M2-Exos) in
enhancing tendon-to-bone healing in aged rats by mitigating cellular senescence of bone …
enhancing tendon-to-bone healing in aged rats by mitigating cellular senescence of bone …
Biologic Adjuvants to Rotator Cuff Repairs Induce Anti-inflammatory Macrophage 2 Polarization and Reduce Inflammatory Macrophage 1 Polarization In Vitro
BC Hawthorne, S Engel, MBR McCarthy… - … : The Journal of …, 2024 - Elsevier
Purpose To examine the effect of various biologic adjuvants on the polarization of
macrophages in an in vitro model for rotator cuff tears. Methods Tissue was harvested from 6 …
macrophages in an in vitro model for rotator cuff tears. Methods Tissue was harvested from 6 …
Editorial Commentary: Dasatinib With Quercetin Shows Promise in Decreasing Age-Related Senescence in the Rotator Cuff Tendon—Can It Work Elsewhere?
FA Barber - Arthroscopy: The Journal of Arthroscopic & Related …, 2024 - Elsevier
Cellular senescence is a fundamental mechanism seen in all age-related diseases. Human
supraspinatus tendon and adjacent bursal specimens evaluated for cellular senescence by …
supraspinatus tendon and adjacent bursal specimens evaluated for cellular senescence by …
[PDF][PDF] The Influence of Age on Cellular Senescence in Injured versus Healthy Muscle and Its Implications on Rotator Cuff Injuries
KC Wang, SM Garcia, J Lau, X Liu, BT Feeley - ases-assn.org
Materials and Methods: Muscle biopsies were obtained from individuals undergoing rotator
cuff repair surgery after obtaining informed consent. Deltoid and supraspinatus muscle …
cuff repair surgery after obtaining informed consent. Deltoid and supraspinatus muscle …