Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins

S Thiel - Molecular immunology, 2007 - Elsevier
Mannan-binding lectin (MBL), L-ficolin, M-ficolin and H-ficolin are all complement activating
soluble pattern recognition molecules with recognition domains linked to collagen-like …

Rapid separation of bacteria from blood—review and outlook

WG Pitt, M Alizadeh, GA Husseini… - Biotechnology …, 2016 - Wiley Online Library
The high morbidity and mortality rate of bloodstream infections involving antibiotic‐resistant
bacteria necessitate a rapid identification of the infectious organism and its resistance …

Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury

M Zhang, K Takahashi, EM Alicot… - The journal of …, 2006 - journals.aai.org
Reperfusion of ischemic tissues elicits an acute inflammatory response involving serum
complement, which is activated by circulating natural IgM specific to self-Ags exposed by …

Complement-mediated ischemia-reperfusion injury: lessons learned from animal and clinical studies

GMP Diepenhorst, TM van Gulik, CE Hack - Annals of surgery, 2009 - journals.lww.com
Ischemia-reperfusion (I/R) injury provides a substantial limitation to further improvements in
the development of therapeutic strategies for ischemia-related diseases. Studies in animal …

Immunodeficiency and genetic defects of pattern-recognition receptors

MG Netea, JWM van der Meer - New England Journal of …, 2011 - Mass Medical Soc
Immunodeficiency and Genetic Defects of Pattern-Recognition Receptors | New England Journal
of Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia

F Orsini, P Villa, S Parrella, R Zangari, ER Zanier… - Circulation, 2012 - Am Heart Assoc
Background—The involvement of the complement system in brain injury has been scarcely
investigated. Here, we document the pivotal role of mannose-binding lectin (MBL), one of …

Complement mediators in ischemia–reperfusion injury

TV Arumugam, T Magnus, TM Woodruff, LM Proctor… - Clinica Chimica …, 2006 - Elsevier
BACKGROUND: Ischemia–reperfusion (I/R) injury occurs when a tissue is temporarily
deprived of blood supply and the return of the blood supply triggers an intense inflammatory …

Complex two-gene modulation of lung disease severity in children with cystic fibrosis

R Dorfman, A Sandford, C Taylor… - The Journal of …, 2008 - Am Soc Clin Investig
Although cystic fibrosis (CF) is a monogenic disease, its clinical manifestations are
influenced in a complex manner. Severity of lung disease, the main cause of mortality …

High glucose disrupts oligosaccharide recognition function via competitive inhibition: a potential mechanism for immune dysregulation in diabetes mellitus

R Ilyas, R Wallis, EJ Soilleux, P Townsend, D Zehnder… - Immunobiology, 2011 - Elsevier
Diabetic complications include infection and cardiovascular disease. Within the immune
system, host–pathogen and regulatory host–host interactions operate through binding of …

The genetics of ficolins

P Garred, C Honoré, YJ Ma, S Rørvig… - Journal of innate …, 2009 - karger.com
Ficolins constitute a family of proteins whose biological role has been an enigma for many
years. Over the past few years it has become evident that ficolins are part of the innate …