In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …

RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work
conducted over the last decades has defined the major mRNA decay pathways, as well as …

Aneuploidy is highly detrimental during development yet common in cancers and
pathogenic fungi–what gives rise to differences in aneuploidy tolerance remains unclear …

RNA uridylation is a potent and widespread posttranscriptional regulator of gene
expression. RNA uridylation has been detected in a range of eukaryotes including …

RNA decay plays a major role in regulating gene expression and is tightly networked with
other aspects of gene expression to effectively coordinate post-transcriptional regulation …

Different levels of regulatory mechanisms, including posttranscriptional regulation, are
needed to elaborately regulate inflammatory responses to prevent harmful effects. Terminal …

The synthesis of ribosomal subunits in eukaryotes requires the interplay of numerous
maturation and assembly factors (AFs) that intervene in the insertion of ribosomal proteins …

Uridylation emerges as a key modification promoting mRNA degradation in eukaryotes. In
addition, uridylation by URT1 prevents the accumulation of excessively deadenylated …

It is well established that mRNA steady‐state levels do not directly correlate with
transcription rate. This is attributed to the multiple post‐transcriptional mechanisms, which …

Groundbreaking discoveries have uncovered the widespread post-transcriptional
modifications of all classes of RNA. These studies have led to the emerging notion of an …