Endochondral ossification is a carefully orchestrated process mediated by promoters and
inhibitors of mineralization. Phosphatases are implicated, but their identities and functions …

Introduction 3. Morphology of matrix vesicles (MVs) 3.1. Conventional transmission electron
microscopy 3.2. Cryofixation, freeze-substitution electron microscopy 3.3. Freeze-fracture …

A review and discussion of new knowledge on the structure and function of mammalian
alkaline phosphatases (APs) gained over the last 25 years. It covers:* The structure …

Endochondral ossification is a carefully orchestrated process mediated by promoters and
inhibitors of mineralization. Phosphatases are implicated, but their identities and functions …

PHOSPHO1 is a phosphatase highly expressed in bone. We studied its functional
involvement in mineralization through the use of novel small molecule inhibitors …

Human PHOSPHO1 is a phosphatase enzyme for which expression is upregulated in
mineralizing cells. This enzyme has been implicated in the generation of Pi for matrix …

Since its characterization two decades ago, the phosphatase PHOSPHO1 has been the
subject of an increasing focus of research. This work has elucidated PHOSPHO1's central …

Mineralisation of bone and cartilage is essential for skeletal development and function. We
have previously reported a novel gene (PHOSPHO1); a member of the large haloacid …

Shoot-to-root communication is crucial for plant acclimation to phosphorus (P)-deficiency.
Both sugars and miRNAs have been implicated as potential signal molecules transported …

Epidemiological evidence conclusively demonstrates that calcium burden is a significant
predictor of cardiovascular morbidity and mortality; however, the underlying mechanisms …