HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …

Maternal-fetal immune-tolerance occurs throughout the whole gestational trimester, thus a
mother can accept a genetically distinct fetus without immunological aggressive behavior …

HLA-G is a non-classical HLA class I molecule with immunomodulatory properties. It was
initially described at the maternal-fetal interface, and it was later found that this molecule …

HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-
G coding region has been maintained during the evolution process, in which most of its …

Human leukocyte antigen G (HLA-G) belongs to the family of non-classical HLA class I
genes, located within the major histocompatibility complex (MHC). HLA-G has been the …

BACKGROUND Although the immune system intuitively must have an important role in
embryo implantation and in the achievement of a pregnancy, the molecular details have for …

The non-classical HLA-G is a well-known immune-modulatory molecule. In physiological
condition, HLA-G surface expression is restricted to the maternal–fetal interface and to …

Embryo implantation failure and spontaneous abortions represent the main causes of
infertility in developed countries. Unfortunately, incomplete knowledge of the multiple factors …

The human leukocyte antigen (HLA)-G is a non-classical HLA class I molecule, which has
distinct features to classical HLA-A,-B,-C antigens, such as a low polymorphism, different …

Background Fetal immune tolerance is crucial for pregnancy success. We studied the link
between preeclampsia, a severe pregnancy disorder with uncertain pathogenesis, and fetal …