Generation of autoantibodies against glycated fibrinogen: Role in diabetic nephropathy and retinopathy

A Khanam, S Alouffi, AR Alyahyawi, A Husain… - Analytical …, 2024 - Elsevier
The process of glycation, characterized by the non-enzymatic reaction between sugars and
free amino groups on biomolecules, is a key contributor to the development and progression …

Biophysical, biochemical, and molecular docking investigations of anti-glycating, antioxidant, and protein structural stability potential of garlic

MWA Khan, AA Otaibi, AKD Alsukaibi, EM Alshammari… - Molecules, 2022 - mdpi.com
Garlic has been reported to inhibit protein glycation, a process that underlies several
disease processes, including chronic complications of diabetes mellitus. Biophysical …

Pharmacological Profile of Nigella sativa Seeds in Combating COVID-19 through In-Vitro and Molecular Docking Studies

S Sherwani, S Rajendrasozhan, MWA Khan, M Saleem… - Processes, 2022 - mdpi.com
COVID-19 infection is associated with elevated oxidative stress, systemic hyper-
inflammatory responses, endothelial dysfunction, and red blood cell membrane …

Real-time in-situ quantification of protein secondary structures in aqueous solution based on ATR-FTIR subtraction spectrum

J Zhao, JK Cui, RX Chen, ZZ Tang, ZL Tan… - Biochemical …, 2021 - Elsevier
Abstract Changes occur in protein secondary structures during food processing,
pharmaceutical research, and enzymatic reactions, etc. To date, most studies to quantify the …

Short-chain β-manno-oligosaccharides from copra meal: structural characterization, prebiotic potential and anti-glycation activity

A Shubhashini, N Prabha, P Monica, SR Chaudhari… - Food & Function, 2022 - pubs.rsc.org
Size-exclusion chromatography, HR-ESI-MS and FT-IR of copra meal hydrolyzed by ManB-
1601 showed the presence of oligosaccharides (CM-β-MOS) having a degree of …

Synthesis, Characterization, Antiglycation Evaluation, Molecular Docking, and ADMET Studies of 4-Thiazolidinone Derivatives

A Haque, MWA Khan, KM Alenezi, R Soury… - ACS …, 2023 - ACS Publications
The design and development of new small-molecule glycation inhibitors are essential for
preventing various chronic diseases, including diabetes mellitus, immunoinflammation …

[HTML][HTML] Pharmacological Activities of Zingiber officinale Roscoe: Inhibition of HSA Protein Glycation, Structure Stability and Function Restoration

MWA Khan, S Sherwani, MHE Alshammari… - Pharmaceuticals, 2024 - mdpi.com
Background: Controlled non-enzymatic glycation reactions are common under normal
physiological conditions. However, during elevated blood glucose conditions, the glycation …

Enhanced biological activity of Curcumin Cinnamates: an experimental and computational analysis

NG Gogoi, A Rahman, J Saikia, P Dutta… - Medicinal Chemistry …, 2022 - Springer
The binding of bioactive component in a drug molecule with proteins is important for their
delivery at the target site in vivo. Bovine serum albumin (BSA) and human serum albumin …

Inhibition and Mechanism of Protein Nonenzymatic Glycation by Lactobacillus fermentum

Q Li, K Xiao, C Yi, F Yu, W Wang, J Rao, M Liu… - Foods, 2024 - mdpi.com
Lactobacillus fermentum (L. fermentum) was first evaluated as a potential advanced
glycation end-product (AGE) formation inhibitor by establishing a bovine serum albumin …

Increased levels of autoantibodies against ROS-modified proteins in depressed individuals with decrease in antibodies against SARS-CoV-2 antigen (S1-RBD)

S Sherwani, M Raafat, S Rajendrasozhan… - Current Issues in …, 2022 - mdpi.com
Coronavirus 2019 (COVID-19) disease management is highly dependent on the immune
status of the infected individual. An increase in the incidence of depression has been …