Cyclic peptides have been attracting a lot of attention in recent decades, especially in the
area of drug discovery, as more and more naturally occurring cyclic peptides with diverse …

Cyclic peptides are molecules that are already used as drugs in therapies approved for
various pharmacological activities, for example, as antibiotics, antifungals, anticancer, and …

Conspectus Synthetic proteins are expected to go beyond the boundary of recombinant
DNA expression systems by being flexibly installed with site-specific natural or unnatural …

Peptides are increasingly important drug candidates, offering numerous advantages over
conventional small molecules. However, they face significant challenges related to stability …

l-Enduracididine (l-End) is a nonproteinogenic amino acid found in a number of bioactive
peptides, including the antibiotics teixobactin, enduracidin, and mannopeptimycin. The …

Highlights•Serine/threonine ligation has been developed for the chemical synthesis of
proteins.•Ser/Thr ligation-mediated cyclization can be used for cyclic peptides …

Based on a mechanism analogous to the serine/threonine ligation, the aspartic acid ligation,
which is facilitated by the γ-amino alcohol based ligation and oxidation, is developed and …

The ligation-mediated total synthesis of corramycin, a myxobacterial natural product of the
strain Corallococcus coralloides, is presented. The synthetic strategy included using two …

Herein, we report the development of a facile synthetic strategy for constructing diverse
peptide structural architectures via chemoselective peptide ligation. The key advancement …

Cancer is one of the leading diseases, which, in the most cases, ends with death and, thus,
continues to be a major concern in human beings worldwide. The conventional anticancer …