Amyloids are protein aggregates with a specific filamentous structure that are related to a
number of human diseases, and also to some important physiological processes in animals …

In both prokaryotes and eukaryotes, the expression of a large number of genes is controlled
by negative feedback, in some cases operating at the level of translation of the mRNA …

Protein synthesis (translation) is one of the fundamental processes occurring in the cells of
living organisms. Translation can be divided into three key steps: initiation, elongation, and …

[PSI+] is the prion form of the translation termination factor Sup35 (eRF3);[PSI+] strains
display nonsense suppression. Another prion‐like element,[ISP+], is linked to …

Mcm1 is an essential Q/N-rich transcription factor. Q/N-rich proteins interact with each other,
and many affect the [PSI+] prion formed by the translation termination factor Sup35 (eRF3) …

Expansion of polyglutamine stretches in several proteins causes neurodegenerative
amyloidoses, including Huntington disease. In yeast, mutant huntingtin (mHtt) with a stretch …

Eukaryotic release factor 1 (eRF1) is a translation termination factor that binds to the
ribosome at stop codons. The expression of eRF1 is strictly controlled, since its …

Termination of translation in eukaryotes is governed by two release factors encoded by the
SUP45 and SUP35 genes in Saccharomyces cerevisiae. Previously, a set of mutations in …

The essential eukaryote release factor eRF1, encoded by the yeast SUP45 gene,
recognizes stop codons during ribosomal translation. SUP45 nonsense alleles are …

Previously, we described and characterized the yeast nonchromosomal determinant [NSI+],
which possesses prion properties. This determinant causes a decrease in fidelity of …