Approximately one percent of the human genome encodes proteins that either regulate or
are regulated by direct interaction with members of the Rho family of small GTPases …

Cadherin cell-adhesion proteins mediate many facets of tissue morphogenesis. The
dynamic regulation of cadherins in response to various extracellular signals controls cell …

This review addresses the cellular and molecular mechanisms of cadherin-based tissue
morphogenesis. Tissue physiology is profoundly influenced by the distinctive organizations …

p120-catenin stabilizes epithelial cadherin (E-cadherin) in SW48 cells, but the mechanism
has not been established. Here, we show that p120 acts at the cell surface to control …

Cohesive sheets of epithelial cells are a fundamental feature of multicellular organisms and
are largely a product of the varied functions of adherens junctions. These junctions and their …

Cell migration is a process which is essential during embryonic development, throughout
adult life and in some pathological conditions. Cadherins, and more specifically the neural …

Wound healing involves a coordinated series of tissue movements that bears a striking
resemblance to various embryonic morphogenetic episodes. There are several ways in …

The mechanisms that order cellular packing geometry are critical for the functioning of many
tissues, but they are poorly understood. Here, we investigate this problem in the developing …

Integration of receptor tyrosine kinase, integrin, and cadherin activities is crucial for normal
cell growth, motility, and adhesion. Here, we describe roles for p120-catenin (p120) and …

The biological impact of Rho depends critically on the precise subcellular localization of its
active, GTP-loaded form. This can potentially be determined by the balance between …