Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles
Extracellular vesicles (EVs) are gaining ground as next-generation drug delivery modalities.
Genetic fusion of the protein of interest to a scaffold protein with high EV-sorting ability …
Genetic fusion of the protein of interest to a scaffold protein with high EV-sorting ability …
Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads
K Leandro, D Rufino-Ramos, K Breyne… - Advanced Drug Delivery …, 2024 - Elsevier
Gene editing technologies have the potential to correct genetic disorders by modifying,
inserting, or deleting specific DNA sequences or genes, paving the way for a new class of …
inserting, or deleting specific DNA sequences or genes, paving the way for a new class of …
Exploring the clinical transition of engineered exosomes designed for intracellular delivery of therapeutic proteins
M Kim, H Choi, DJ Jang, HJ Kim, Y Sub… - Stem Cells …, 2024 - academic.oup.com
Extracellular vesicles, particularly exosomes, have emerged as promising drug delivery
systems owing to their unique advantages, such as biocompatibility, immune tolerability, and …
systems owing to their unique advantages, such as biocompatibility, immune tolerability, and …
The Discovery of Extracellular Vesicles and Their Emergence as a Next-Generation Therapy
From their humble discovery as cellular debris to cementing their natural capacity to transfer
functional molecules between cells, the long-winded journey of extracellular vesicles (EVs) …
functional molecules between cells, the long-winded journey of extracellular vesicles (EVs) …
Defining tropism and activity of natural and engineered extracellular vesicles
Extracellular vesicles (EVs) have important roles as mediators of cell-to-cell communication,
with physiological functions demonstrated in various in vivo models. Despite advances in …
with physiological functions demonstrated in various in vivo models. Despite advances in …
Novel endogenous engineering platform for robust loading and delivery of functional mRNA by extracellular vesicles
AM Zickler, X Liang, D Gupta, D Mamand, MD Luca… - bioRxiv, 2023 - biorxiv.org
Messenger RNA (mRNA) has emerged as an attractive therapeutic molecule for a range of
clinical applications. For in vivo functionality, mRNA therapeutics require encapsulation into …
clinical applications. For in vivo functionality, mRNA therapeutics require encapsulation into …
An extracellular vesicle delivery platform based on the PTTG1IP protein
CM Perez, X Liang, D Gupta, M Conceição, I Mäger… - bioRxiv, 2023 - biorxiv.org
Extracellular vesicles (EVs) hold great promise as therapeutic delivery vehicles, although
their potential is limited by a lack of efficient EV engineering strategies to enhance loading …
their potential is limited by a lack of efficient EV engineering strategies to enhance loading …
Identification of Novel Scaffold Proteins for Improved Endogenous Engineering of Extracellular Vesicles
W Zheng, J Rädler, H Sork, Z Niu, S Roudi, J Bost… - bioRxiv, 2023 - biorxiv.org
Extracellular vesicles (EVs) are gaining ground as next-generation drug delivery modalities.
Genetic fusion of the protein of interest to a scaffold protein with high EV-sorting ability …
Genetic fusion of the protein of interest to a scaffold protein with high EV-sorting ability …