Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …

Nitrite is one of the players in the broad nitrogen biogeochemical cycle. This nitrogen oxo-
anion is involved in key pathways crucial to life on Earth and to the planetary “recycling” of …

The induced pluripotent stem (iPS) cell field holds promise for in vitro disease modeling.
However, identifying innate cellular pathologies, particularly for age-related …

Most reactive oxygen species (ROS) are generated in cells by the mitochondrial respiratory
chain. Mitochondrial ROS production is modulated largely by the rate of electron flow …

AIMS: Poor blood flow and hypoxia/ischemia contribute to many disease states and may
also be a factor in the decline of physical and cognitive function in aging. Nitrite has been …

Endothelial cells are covered by a delicate meshwork of glycoproteins known as the
glycocalyx. Under normophysiological conditions the glycocalyx plays an active role in …

Currently, light therapies are widely used in both human and veterinarian medicine. The
application of light to clinical therapeutics includes: photodynamic therapy, used to kill …

We report that Rcf1 (formerly Aim31), a member of the conserved hypoxia-induced gene 1
(Hig1) protein family, represents a novel component of the yeast cytochrome bc 1 …

The rate that hemoglobin reacts with nitric oxide (NO) is limited by how fast NO can diffuse
into the heme pocket. The reaction is as fast as any ligand/protein reaction can be and the …

It is now accepted that the anion nitrite, once considered an inert oxidation product of nitric
oxide (NO), contributes to hypoxic vasodilation, physiological blood pressure control, and …