Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as
a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The …

Chronic obstructive pulmonary disease (COPD) is a major and increasing global health
problem that is now a leading cause of death. COPD is associated with a chronic …

The mechanisms underlying the action of the potent anti-inflammatory interleukin-10 (IL-10)
are poorly understood. Here we show that, in murine macrophages, IL-10 induces …

Cardiosphere‐derived cells (CDC s) reduce myocardial infarct size via secreted
extracellular vesicles (CDC‐EVs), including exosomes, which alter macrophage …

Objective: To summarize the structure, function, and regulation of matrix metalloproteinases
(MMPs) and to review the literature to date on their potential role in the pathogenesis of …

Met tyrosine kinase receptor, also known as c-Met, is the HGF (hepatocyte growth factor)
receptor. The HGF/Met pathway has a prominent role in cardiovascular remodelling after …

Interleukins are considered to be key players in the chronic vascular inflammatory response
that is typical of atherosclerosis. Thus, the expression of proinflammatory interleukins and …

Objectives: We evaluated whether renin-angiotensin system (RAS) blockade attenuates
cardiovascular events. Background: Because inflammation and enhanced thrombogenesis …

The mechanisms by which IL-6 contributes to the pathogenesis of chronic inflammatory
diseases and cancer are not fully understood. We previously reported that cyclooxygenase …

The macrophage lineage displays extreme functional and phenotypic heterogeneity, which
appears to be because, in large part, of the ability of macrophages to functionally adapt to …