Severe periodontitis, a destructive inflammatory disease of the supporting tissues of the
teeth, ranks sixth in terms of global spread, affecting about 11% of the population …

Lung cancer is a major global health problem, as it is the leading cause of cancer-related
deaths worldwide. Major advances in the identification of key mutational alterations have led …

Periodontitis are infectious diseases characterized by immune-mediated destruction of
periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key …

Membrane-type matrix metalloproteases (MT-MMP) are pivotal regulators of cell invasion,
growth and survival. Tethered to the cell membranes by a transmembrane domain or GPI …

Endometriosis is a condition that is influenced by hormones and involves stroma and glands
being found outside the uterus; there are increases in proliferation, invasion, internal …

The dissemination of tumor cells to local and distant sites presents a significant challenge in
the clinical management of many solid tumors. These cells may remain dormant for months …

Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The
expression and function of the membrane-type matrix metalloproteinase MMP14 is closely …

We performed whole transcriptome analysis of osteosarcoma bone samples. Initially, we
sequenced total RNA from 36 fresh-frozen samples (18 tumoral bone samples and 18 non …

Tissue inhibitors of matrix metalloproteinases (TIMP) are a family of four endogenous
proteins that primarily function to inhibit the activities of proteases such as the matrix …

The abnormal tumor microenvironment (TME) often dictates the therapeutic response of
cancer to chemo-and immuno-therapy. Aberrant expression of pericentromeric satellite …